8/n Let's compare to another paper - Mahmud (2020) is a study that everyone would agree is at low risk of bias. It is just incredibly well done Also, it found a benefit for ivermectinhttps://journals.sagepub.com/doi/10.1177/03000605211013550?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed …
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@threadreaderapp unroll pls -
Hola, you can read it here: Another day, another systematic review and meta-analysis of the same… https://threadreaderapp.com/thread/1412635807702142982.html … Talk to you soon.
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I see they didn't include the largest placebo controlled trial on this to date which found no significant result? https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-021-06348-5 … Perhaps it was too new?
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Yeh it was only published a few days ago
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Without risk-benefit analysis? Say 50% chance it does NOT work (given the right bias in the right study) + 50% chance that it works with an RR of ~0.30 (found by reviews) => gives you E(RR) ~ 0.65, which is still substantial
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Question isnt: are we 100% sure. Question is, is there more than 50% chance it doesnt work? (I wouldnt think so - I'd say there is a chance it doesnt work.) But that still leads to a recommendation? You can never be 100% sure a drug helps you.. that's pointless
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Salam, you can read it here: Another day, another systematic review and meta-analysis of the same… https://threadreaderapp.com/thread/1412635807702142982.html … Enjoy :)
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Which would make the argument for robust debate on the matter, which social media has made impossible for the lay public. A dangerous precedent.
Thanks. Twitter will use this to make your timeline better. UndoUndo
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@threadreaderapp unroll please -
Hola, here is your unroll: Another day, another systematic review and meta-analysis of the same… https://threadreaderapp.com/thread/1412635807702142982.html … Share this if you think it's interesting.
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