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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK Jun 21

      19/n This sort of finicky examination is where it gets really, really tough, because like I said, it's a bit subjective. I don't really care either way about the studies included, but people can (and probably will) disagree

      1 reply 1 retweet 20 likes
      Show this thread
    2. Health Nerd‏Verified account @GidMK Jun 21

      20/n That being said, I quickly redid the meta-analysis excluding these two quite weird studies, and the results completely change, with no significance at all (RR 0.72, 0.41-1.25) Make of that what you willpic.twitter.com/8ucUe40gq3

      1 reply 13 retweets 75 likes
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    3. Health Nerd‏Verified account @GidMK Jun 21

      21/n Even if you ignore my opinions, limiting the analysis to only studies rated BY THE AUTHORS as "low" risk of bias gives you a completely inconclusive result (RR 0.65, 0.12-3.59) 🤷‍♂️

      1 reply 6 retweets 62 likes
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    4. Health Nerd‏Verified account @GidMK Jun 21

      22/n So I don't really have an issue with the methodology or the results of the study, except to say that I think the risk of bias here is generally quite high and publication bias is likely The conclusions however...

      1 reply 2 retweets 42 likes
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    5. Health Nerd‏Verified account @GidMK Jun 21

      23/n I don't think this is justified at all to be honest. Even if we ignore the issues that I mentioned in this thread, most of these studies are really short (probably because they're all preprints) containing only a fraction of the information you need to properly assess thempic.twitter.com/8tX77GMESA

      1 reply 6 retweets 46 likes
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    6. Health Nerd‏Verified account @GidMK Jun 21

      24/n There's a good reason the risk of bias for so many regions here is 'unclear' - the studies simply don't include enough information! Often the methods sections are 3-4 paragraphs long (v. short for an RCT)pic.twitter.com/8AP18DKtD2

      2 replies 2 retweets 33 likes
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    7. Health Nerd‏Verified account @GidMK Jun 21

      25/n Moreover, publication bias looks to be a bit of an issue, and it's not really addressed. Quite likely to be some null findings that are floating around but will be published eventually!

      1 reply 1 retweet 28 likes
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    8. Health Nerd‏Verified account @GidMK Jun 21

      26/n On top of this, if you only look at studies that the authors have rated as having a low risk of bias for all domains, the evidence is pretty much squarely null, although this is limited by the fact that there are only 3 good studies

      3 replies 4 retweets 33 likes
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    9. Health Nerd‏Verified account @GidMK Jun 21

      27/n I don't think that this study really supports the use of ivermectin as a treatment for COVID-19 outside of a clinical trial, which is a shame because it'd be fantastic to have another effective drug for the disease

      4 replies 7 retweets 74 likes
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    10. Ivermectin Research Alliance‏ @RealIvermectin Jun 21
      Replying to @GidMK

      Look very closely at the Chamie paper.

      1 reply 0 retweets 1 like
      Health Nerd‏Verified account @GidMK Jun 21
      Replying to @RealIvermectin

      That was excluded from this review because it is not an RCT I believe

      6:08 PM - 21 Jun 2021
      • 2 Likes
      • 💧 Ian "Department of Diseasology" 🍩 Musgrave (((Dorit Reiss)))
      3 replies 0 retweets 2 likes

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