10/n Now, it's a bit weird to exclude people who've taken vitamin D supplements 3 months ago from this sample anyway - most of the people were deficient in vitamin D despite the supplements - but there's also more that's strange here
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11/n For one thing, even though people have been EXCLUDED from the trial, the control group has...increased? 379 in the preprint, 391 in the publicationpic.twitter.com/HRwuUjeP5Z
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12/n This is not explained - the only thing mentioned is that 92 people were excluded ~prior to the trial~ Were people moved from treatment to control? How does that happen in a prospective cohort study?pic.twitter.com/zhmbGrsZhq
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13/n Table 1 also has some mistakes. For example, the obesity numbers and percentages have been copied in wrongpic.twitter.com/E04Q7JY91Q
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14/n The figures in Table 1 are also just a bit...odd? 20% diabetes, 30% dyslipidemia, but only 9% of people with BMI>30? Are those obesity values just an error perhaps?
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15/n There are also tons of strange small differences between the preprint and the published study. 80/379 died in the control group in the preprint, but 82/391 died in the publication None of this is explained
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16/n At this point I just honestly don't know what to make of the research. As an observational study, it's not very meaningful (if nothing else, there's no control for or discussion of how patients were allocated to the wards)
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17/n As a randomized study that was retracted from SSRN after being rejected from the Lancet, it is pretty problematic that the preprint isn't mentioned at all in the published work, and that the differences aren't really explained
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Health Nerd Retweeted Covid19Crusher
18/n If anyone was wondering, this study is being touted as proof that vitamin D is a miracle cure for COVID-19 despite the innumerable weaknesses, because of course it is!https://twitter.com/Covid19Crusher/status/1402320259626016772?s=20 …
Health Nerd added,
Covid19Crusher @Covid19CrusherPeer-reviewed, quasi-randomized propective trial (n=838) of fast acting Vitamin D (Calcifediol) in Spain reveals a massive mortality benefit. It is a tragedy not to have this as Standard of Care. https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgab405/6294179 … pic.twitter.com/5IDHOzYxUd2 replies 0 retweets 22 likesShow this thread -
To the tune of your favourite ditty:
you can put any numbers into a random-effects model, but if they're based on terrible research your output is meaningless and you've waaaaaasted your time
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