Here is my first analysis of the new @IHU_Marseille preprint called 'Early Treatment with Hydroxychloroquine and Azithromycin in 10,429 COVID-19 Outpatients: A Monocentric Retrospective Cohort Study'
Found here: (not sure why in April 2020 folder).
https://mediterranee-infection.com/wp-content/uploads/2020/04/MS-IHU-Preprint.pdf …
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Replying to @MicrobiomDigest @IHU_Marseille
Some additional points: they report adhering to STROBE guidelines, but they don't (to be fair, no one ever does) - no discussion of missing data/errors, statistical methods in the supplementaries, no demographics (even though this was almost certainly collected)
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The use of the term "IFR" throughout is boringly wrong. Infection fatality rate is the rate using a denominator of ALL INFECTIONS in a population, what they are reporting here is CASE fatality rate (for cases presenting to outpatients)
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Their interpretation of the odds ratio is wrong (again, very common error) - this would be true if they had calculated relative risks, but they are reporting the results of a logistic regression (to be fair, with such low numbers they are likely to be similar)pic.twitter.com/eDtcT4iWA9
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The controls in the study are insufficient for any meaningful conclusions. They clearly have access to comorbidity and other data (they calculated CCI/NEWS-2 scores for some patients) so it's weird they didn't uses these
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The clearly don't because they state it in the discussion part, so no idea how they calculated NEWS (not 2 I think, at the IHU) scorepic.twitter.com/0hb602cZ2B
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That's a weird contradiction, because they calculated CCI/NEWS for people who died (or at least they report doing so in the supplementary) so did they only get this data for a small group? How? Why not for everyone?
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Probably they did not follow up on the one they treated, only the dead... But also and mostly cause of him ?pic.twitter.com/W6kUSWUVJN
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