There are massive issues with this trial.
The primary outcome at commencement was fMRI
The primary outcome at completion was fMRI
The primary outcome on NCT is still fMRI.
The primary outcome in @NEJM is a clinical scale.
But calling an NNT of 4.x "negative" is a bit much.https://twitter.com/JD_Rosenblat/status/1382487323607191556 …
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Yeah. It was QIDS in protocol v1, already fMRI at v5 (at commencement), still fMRI at v7 (at conclusion) then changed back some time in November. Which is a problem with protocolised unbinding completed in October.
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I think most people say that provided it's some time pre database un-blinding it's fine, but I think that's rubbish personally (but recognise that's a minority view).
End of conversation
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