Full disclosure: someone asked me this and I have no idea so plz enlighten me because I'm sure the answer is super interesting but immunology is HARD
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I don't know but assumed it was because JJ did a study of 1 dose whereas others didn't
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That's true, and I can tell you that one dose works for J&J by reading the research, but explaining the mechanisms...I need help
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It’s a really good spike antigen. I think it’s probably as simple as that.
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Is there reason to believe that immunity may last longer from one vax vs the other? What's the current theory on immunity duration? Seems like the immune system memory wouldn't depend on specific spike composition.
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I don't think you can easily compare the mRNA vaccines to JJJ; with AZ though the immunogen is native spike but the JJJ vaccine used prefusion-stabilized spike which is a superior immunogen. But my go-to on this is always Phase 1/2 studies said so
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Lol that's my go-to answer but I want to know WHY they said so



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What if the answer is just because that's the way they did the trial? And maybe can't give two doses of the type of vaccine technology that J&J uses?
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That is the answer. Here are the phase 1/2 data that gave the company the confidence to run the trial as single dose: https://www.medrxiv.org/content/10.1101/2020.09.23.20199604v1.full.pdf …
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Most likely it was a clinical trial decision. It would have looked terrible if the vaccines didn’t meet efficacy requirements for FDA with a novel tech. So they made it 2 shots to make sure it hit the clinical endpoint. Call it abundance of caution. Or covering yo ass.
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Agreed (with the clarification that the novel tech is not the J&J version).
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