Which comes first, high insulin or obesity?
Conventional view:
weight →
insulin (ins resistance)
New study:
insulin →
weight
Raises new possibilities for obesity treatment
Consistent with Carb-Insulin Model of Obesity
h/t @bschermdhttps://jamanetwork.com/journals/jamanetworkopen/fullarticle/2777423 …
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Replying to @davidludwigmd @bschermd
I'm confused. How is this consistent with the CIM? This is about fasting insulin. CIM is about the post prandial insulin surge following CHO meals, causing the internal starvation state that drives further intake - is it not?
5 replies 2 retweets 41 likes -
Am I missing something here or is this association *only* in people who had gotten bariatric surgery? If so, that should dramatically change the conclusions we can draw.pic.twitter.com/NtelyHPa9K
3 replies 0 retweets 14 likes -
Replying to @TamarHaspel @JohnSpeakman4 and
Am I missing something here or is everyone jumping on these results w/out having considered the quality of a) the review & b) the data therein? How do we know we don’t have GIGO (no, not CICO)? A quick check: n=90 for main finding, Obs studies = Low/very low certainty likely
2 replies 0 retweets 5 likes -
Replying to @dnunan79 @TamarHaspel and
Looks like the review used a fairly loose risk of bias rating system and even then found that a majority of the included research was high risk in at least one areapic.twitter.com/yIszy36PbB
2 replies 0 retweets 2 likes -
Not sure the protocol was registered....
2 replies 0 retweets 2 likes -
Replying to @davykevinp @dnunan79 and
They don't report registering it and I can't find it in PROSPERO by searching author names or title. Might've put it somewhere but if so it should be in the study!
1 reply 0 retweets 2 likes
Of course, this contradicts their statement that they adhered to PRISMA reporting standards, but that's almost ubiquitous in SR/MAs sadly
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Replying to @GidMK @davykevinp and
David Nunan Retweeted David Nunan
Wait, what! A study published in JAMA which requires authors to submit a completed checklist doesn’t actually adhere to said checklist?https://twitter.com/dnunan79/status/1357779845472808966 …
David Nunan added,
0 replies 0 retweets 3 likesThanks. Twitter will use this to make your timeline better. UndoUndo
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