Which comes first, high insulin or obesity?
Conventional view:
weight →
insulin (ins resistance)
New study:
insulin →
weight
Raises new possibilities for obesity treatment
Consistent with Carb-Insulin Model of Obesity
h/t @bschermdhttps://jamanetwork.com/journals/jamanetworkopen/fullarticle/2777423 …
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Yeah downs and black is one (not much used) tool to assess RoB is obs studies. I need to read fully to se how RoB is incorporated into conclusions, but other important issues like consistency, precision, information size, directness etc need to be considered.
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Yeh, given it's mostly obs research it's problematic in my opinion that there's no assessment for pretty basic stuff like rating selection bias in the paper
End of conversation
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Not sure the protocol was registered....
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That’s the spirit. Methods first people! Methods first. Some journals have stated they won’t accept a systematic review that wasn’t registered. Why? Partly because of the risk of this:https://catalogofbias.org/biases/data-dredging-bias/ …
End of conversation
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