Massive news. We knew recruitment had halted, but this is the first published work showing that convalescent plasma probably doesn't work for COVID-19https://twitter.com/MartinLandray/status/1369666410956419078 …
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Unlike hydroxychloroquine, which was always more political than scientific, CP was a good bet that people used because it was hopefully better than nothing
That being said, in the US ~alone~ it was given to 10,000s of people before a randomized trial was even started! This is a HUGE issue imo
RECOVERY is a shining gem of research brilliance, but the capacity to do a similar study exists in dozens of places. Why do we only have one? Why did we have to wait a year for CP results?
Honestly though, it's not all bad- the widespread use of convalescent plasma without apparent exacerbation of patients' clinical status is compelling evidence against the possibility of ADE in humans from COVID-19.
What about Gupta labs study of viral evolution in an immunocompromised individual with convalescent plasma, X thousands of cases? Has struck me as having the potential for bad news
Don't forget the additional aspect that it has the potential to provide a non-sterilising selective pressure to generate immune resistant strains in single individuals.
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