The largest/only RCT of microdosing psilocybin (shrooms) for mental health has just come out, and it found no benefit It is also one of the most methodologically beautiful pieces of research I have ever seen. Amazing innovationhttps://elifesciences.org/articles/62878#s2 …
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And at the end of the study, the researchers found that there was no meaningful difference between people randomly allocated to take shrooms compared to those who had taken a placebopic.twitter.com/JRNMmqBmoF
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Now, there are drawbacks to this methodology. Firstly, you can only run a study like this on people who were already planning on microdosing psilocybin and who are easy to find online, which it turns out is a somewhat specific grouppic.twitter.com/hccTGek1eE
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There's also definitely potential for unblinding bias - as the researchers note, it's likely that some people checked to see which pills they were takingpic.twitter.com/c2Q1NAePLV
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But all in all, this is not only a really interesting study answering a useful question, it's also a research innovation that's going to be invaluable for the future of research into illegal drugs
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