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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK Mar 2

      The largest/only RCT of microdosing psilocybin (shrooms) for mental health has just come out, and it found no benefit It is also one of the most methodologically beautiful pieces of research I have ever seen. Amazing innovationhttps://elifesciences.org/articles/62878#s2 …

      4 replies 13 retweets 56 likes
      Show this thread
    2. Health Nerd‏Verified account @GidMK Mar 2

      Doing research on shrooms is hard, because they're mostly illegal and there are a lot of restrictions in most places Much of the research is simply observational, asking people who already take shrooms what they think of the experience

      2 replies 0 retweets 8 likes
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    3. Health Nerd‏Verified account @GidMK Mar 2

      So what did the researchers do? They asked people who were already going to microdose shrooms to BLIND AND RANDOMIZE THEMSELVES Super cool idea, and impressively sound methodologypic.twitter.com/5Hf2SYSXcv

      1 reply 1 retweet 11 likes
      Show this thread
      Health Nerd‏Verified account @GidMK Mar 2

      Basically, they got people to put the drug and a placebo into opaque pills, then randomize the selection of the drug so that they didn't know what they were taking over the course of 4 weeks

      6:38 PM - 2 Mar 2021
      • 9 Likes
      • Katherine White James Pitt Mathematiker plädiert für Ruhe und Rationalität Maxi King 🔴 💉💉 🔴 Kinder schützen Alan Jepa Pihlainen Niamh Ní Nualláin Rebecca Henry 🌍Derfel The Crackpot 🌍
      1 reply 0 retweets 9 likes
        1. New conversation
        2. Health Nerd‏Verified account @GidMK Mar 2

          Is this open to some bias? Yes, absolutely Is it a genius idea that allows you to conduct really difficult research on illegal drugs cheaply and ethically? Also yes

          1 reply 0 retweets 15 likes
          Show this thread
        3. Health Nerd‏Verified account @GidMK Mar 2

          Each participant had 4 weeks of randomly taking either a placebo or psilocybin, then recording their mood and mental health on a dozen questionnaires. A slightly modified randomized-crossover trial

          1 reply 0 retweets 5 likes
          Show this thread
        4. Health Nerd‏Verified account @GidMK Mar 2

          And at the end of the study, the researchers found that there was no meaningful difference between people randomly allocated to take shrooms compared to those who had taken a placebopic.twitter.com/JRNMmqBmoF

          1 reply 0 retweets 6 likes
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        5. Health Nerd‏Verified account @GidMK Mar 2

          Now, there are drawbacks to this methodology. Firstly, you can only run a study like this on people who were already planning on microdosing psilocybin and who are easy to find online, which it turns out is a somewhat specific grouppic.twitter.com/hccTGek1eE

          1 reply 0 retweets 10 likes
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        6. Health Nerd‏Verified account @GidMK Mar 2

          There's also definitely potential for unblinding bias - as the researchers note, it's likely that some people checked to see which pills they were takingpic.twitter.com/c2Q1NAePLV

          2 replies 0 retweets 9 likes
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        7. Health Nerd‏Verified account @GidMK Mar 2

          But all in all, this is not only a really interesting study answering a useful question, it's also a research innovation that's going to be invaluable for the future of research into illegal drugs

          0 replies 0 retweets 9 likes
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        8. End of conversation

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