So, I have an interesting question for #epitwitter and science fans
Is this study actually a randomized controlled trial (RCT)?
https://pubmed.ncbi.nlm.nih.gov/33150385/ pic.twitter.com/kaqkerQHvd
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Looking at the history... Study started recruiting - Jan 2013 Study finished recruiting - Jan 2019 Secondary outcomes added to register - June 2018pic.twitter.com/gA964fhoWI
In other words, the study went for 5 1/2 years before adding these secondary outcomes, which might go a way towards explaining why >50% of the participants have missing data
Back to the original question - given that this is a per-protocol analysis of a subset of the study, with non-random selection on an outcome selected 5 years after the study began, is it fair to publish as an RCT?
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