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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Gorgi Kosev‏ @spion Feb 18
      Replying to @spion @GidMK and

      The point of the argument is, to answer whether Vitamin D is a useful tool in the hospital, you want to use the fastest acting form of Vitamin D. If it takes a week for the levels to rise, thats a week of disease development without Vitamin D

      1 reply 1 retweet 0 likes
    2. Gorgi Kosev‏ @spion Feb 18
      Replying to @spion @GidMK and

      Given that the average time to hospitalization is about 11 days, average time to death is about 22 days, if it does take a week, you're basically measuring the effect of a couple of days of raised levels.

      1 reply 1 retweet 0 likes
    3. Health Nerd‏Verified account @GidMK Feb 18
      Replying to @spion @mattyvau and

      The days until hospitalization thing is a complete red herring. The question here is not whether taking prophylactic vitamin D helps, but whether giving it to sick people does. That's the claim being tested

      1 reply 0 retweets 1 like
    4. Health Nerd‏Verified account @GidMK Feb 18
      Replying to @GidMK @spion and

      As to the raised levels, if vitamin D had a large effect on hospital outcomes, you'd expect to see some impact even if it was delayed by a few hours. So while the study, taken at face value, wouldn't prove definitively that there cannot be a minor benefit

      2 replies 0 retweets 1 like
    5. Gorgi Kosev‏ @spion Feb 18
      Replying to @GidMK @mattyvau and

      I was under the impression that it takes a week for Vitamin D to be processed in the liver, not hours?

      1 reply 0 retweets 0 likes
    6. Gorgi Kosev‏ @spion Feb 18
      Replying to @spion @GidMK and

      then you get 25-hydroxycholecalciferol, which then is further processed (fairly quickly) in the kidneys.

      1 reply 0 retweets 0 likes
    7. Gorgi Kosev‏ @spion Feb 18
      Replying to @spion @GidMK and

      Whereas if you give calcifediol directly (like the Spanish trials did) you can skip the liver processing.

      1 reply 0 retweets 0 likes
    8. Gorgi Kosev‏ @spion Feb 18
      Replying to @spion @GidMK and

      Is this not true?

      1 reply 0 retweets 0 likes
    9. Gorgi Kosev‏ @spion Feb 18
      Replying to @spion @GidMK and

      Ok, damn. Looks like that bit may have been false. https://www.ncbi.nlm.nih.gov/books/NBK56061/ pic.twitter.com/thz7xEIXlg

      1 reply 0 retweets 1 like
    10. Gorgi Kosev‏ @spion Feb 18
      Replying to @spion @GidMK and

      Here is the source where I got the "few days up to a week" bit:https://youtu.be/V8Ks9fUh2k8?t=462 …

      1 reply 0 retweets 0 likes
      Health Nerd‏Verified account @GidMK Feb 18
      Replying to @spion @mattyvau and

      To be *fully* metabolized, it takes a while, but it starts straight away. With such an enormous dose, a lot of it is going to get into the bloodstream quickly. This is why I recommend not watching Youtube as a primary source for information generally 👍

      2:13 PM - 18 Feb 2021
      • 1 Like
      • Matt
      1 reply 0 retweets 1 like
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        2. Gorgi Kosev‏ @spion Feb 18
          Replying to @GidMK @mattyvau and

          Would have been happier to see a chart of the levels over time in the study, but fair enough.

          1 reply 0 retweets 1 like
        3. Health Nerd‏Verified account @GidMK Feb 18
          Replying to @spion @mattyvau and

          I mean, it was a ~huge~ dose. Unless the human body completely reversed in its functioning, these people would very quickly have stopped being deficient. It's an argument used by people who don't like the trial results, not a realistic reason for the study being bad

          1 reply 0 retweets 1 like
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