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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK Feb 17

      The largest randomized-controlled trial to date on vitamin D and COVID-19 has now been published. Headline finding: no benefit for vitamin D in large doses https://jamanetwork.com/journals/jama/fullarticle/2776738?guestAccessKey=f5804d82-41ff-44f8-829f-90c98f52e117&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=olf&utm_term=021721 …pic.twitter.com/nqkiLzNqL2

      35 replies 210 retweets 560 likes
      Show this thread
    2. Phil Hamilton‏ @PhilHam24571318 Feb 18
      Replying to @GidMK @DrDomPimenta

      Yet another study analysing in hospital patients. As far as I can see, supporters of Vit-D are NOT claiming it will have any effect at this late stage of illness. They are claiming that Vit-D can have an effect at early stage, or even before infection

      3 replies 2 retweets 27 likes
    3. Matt‏ @mattyvau Feb 18
      Replying to @PhilHam24571318 @GidMK @DrDomPimenta

      They are claiming multiple things then constantly moving the goalposts. It's what ideology does to people

      2 replies 1 retweet 20 likes
    4. Gorgi Kosev‏ @spion Feb 18
      Replying to @mattyvau @PhilHam24571318 and

      They could have at least used calcifediol to skip liver processing, or measure the 25-OH levels a few more times, not just at the end at hospital discharge. Not clear why the trial didn't do any of the above.

      1 reply 1 retweet 0 likes
    5. Health Nerd‏Verified account @GidMK Feb 18
      Replying to @spion @mattyvau and

      I find these arguments fascinating, because it was a massive dose that entirely reversed any deficiency in the majority of patients, so they just don't really make sense

      1 reply 0 retweets 1 like
    6. Gorgi Kosev‏ @spion Feb 18
      Replying to @GidMK @mattyvau and

      I don't understand. How quickly was the deficiency reversed? Would we expect the levels to go up immediately a day or two after the dose?

      1 reply 1 retweet 0 likes
    7. Gorgi Kosev‏ @spion Feb 18
      Replying to @spion @GidMK and

      The point of the argument is, to answer whether Vitamin D is a useful tool in the hospital, you want to use the fastest acting form of Vitamin D. If it takes a week for the levels to rise, thats a week of disease development without Vitamin D

      1 reply 1 retweet 0 likes
    8. Gorgi Kosev‏ @spion Feb 18
      Replying to @spion @GidMK and

      Given that the average time to hospitalization is about 11 days, average time to death is about 22 days, if it does take a week, you're basically measuring the effect of a couple of days of raised levels.

      1 reply 1 retweet 0 likes
    9. Health Nerd‏Verified account @GidMK Feb 18
      Replying to @spion @mattyvau and

      The days until hospitalization thing is a complete red herring. The question here is not whether taking prophylactic vitamin D helps, but whether giving it to sick people does. That's the claim being tested

      1 reply 0 retweets 1 like
    10. Health Nerd‏Verified account @GidMK Feb 18
      Replying to @GidMK @spion and

      As to the raised levels, if vitamin D had a large effect on hospital outcomes, you'd expect to see some impact even if it was delayed by a few hours. So while the study, taken at face value, wouldn't prove definitively that there cannot be a minor benefit

      2 replies 0 retweets 1 like
      Health Nerd‏Verified account @GidMK Feb 18
      Replying to @GidMK @spion and

      ...it certainly makes benefits of the sort being discussed by proponents much less likely. Like I've said elsewhere, it's entirely possible that there is a modest benefit to giving other forms of vit D earlier in the disease - it's just unlikely to be a panacea

      1:06 PM - 18 Feb 2021
      • 1 Like
      • Jayne Vaccines Work. #JOHNSONOUT
      0 replies 0 retweets 1 like

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