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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK Feb 14

      24/n I should specify that none of this makes the study totally sketchy, it's just all really weird and they are things that the authors should have explained in the paper

      2 replies 2 retweets 58 likes
      Show this thread
    2. Health Nerd‏Verified account @GidMK Feb 14

      25/n Overall, what we have is a study that, if run as specified, was a non-randomized prospective cohort study that gives us very little/no new information on vitamin D for COVID-19

      2 replies 6 retweets 81 likes
      Show this thread
    3. aure‏ @maureviv Feb 15
      Replying to @GidMK

      I've looked a bit into this. In Spain, every RCT must be registered at REEC https://reec.aemps.es/reec/public/web.html … REEC is the national RCT portal In fact, every approval goes through it, allowing communication between the Spanish/European Drug Agencies, the local Commitee & the researchers

      2 replies 2 retweets 11 likes
    4. aure‏ @maureviv Feb 15
      Replying to @maureviv @GidMK

      It is more than a registry; it is the portal where all RCTs are processed, so there's no chance that an approved RCT didn't pass through REEC. Looking for vitamin D RCTs, there's only one ongoing Vit D trial: its identifier is 2020-002312-43 https://reec.aemps.es/reec/estudio/2020-002312-43 …

      1 reply 0 retweets 4 likes
    5. aure‏ @maureviv Feb 15
      Replying to @maureviv @GidMK

      The registered RCT is led by a researcher from the Severo Ochoa hospital; the Hospital del Mar doesn't participate as a recruiting centre Either the published preprint doesn't correspond to an RCT or this is a case of a severe ethical transgression; most probably the former

      1 reply 1 retweet 7 likes
    6. aure‏ @maureviv Feb 15
      Replying to @maureviv @GidMK

      The remaining approved Vitamin D RCTs are stopped, as far as I have found

      1 reply 0 retweets 3 likes
    7. aure‏ @maureviv Feb 15
      Replying to @maureviv @GidMK

      I think the best thing that can be done with this preprint is to reanalyse it as a quasiexperimental study, seeking expert help by an Epidemiologist

      1 reply 0 retweets 1 like
    8. aure‏ @maureviv Feb 15
      Replying to @maureviv @GidMK

      aure Retweeted Nick Brown

      We will wait for the Committee's response but, if nothing is found in REEC there's no chance this is an RCThttps://twitter.com/sTeamTraen/status/1361002525839736832?s=19 …

      aure added,

      Nick Brown @sTeamTraen
      I've written to ask for the ethical protocol of the Barcelona vitamin D study. (There is a strong case to be made for attaching a PDF of the ethical approval document to every manuscript, rather than just giving the internal reference number.) pic.twitter.com/zxOtWTZC14
      1 reply 0 retweets 2 likes
    9. aure‏ @maureviv Feb 15
      Replying to @maureviv @GidMK

      Brief Update, There's an ongoing trial led by Cordoba in which the Hospital del Mar participates (not leads) https://reec.aemps.es/reec/estudio/2020-001717-20 … But the dates of approval don't match the ones declared in the preprint: No RCT was ongoing during the dates written in the preprint

      1 reply 0 retweets 4 likes
    10. aure‏ @maureviv Feb 15
      Replying to @maureviv @GidMK

      First patient recruited in the Cordoba RCT: 5-06-2020 The preprint study was conducted in Barcelona (single centre) between March 1st & May 31st 2020 It seems like observational data collected before a trial, thus the lack of randomisation evidence & methods issues still applypic.twitter.com/O8DJ09wf4U

      1 reply 1 retweet 5 likes
      Health Nerd‏Verified account @GidMK Feb 15
      Replying to @maureviv

      I'm beginning to suspect, based on the author reply and the timeline, that this is actually a retrospective review of medical records

      2:54 PM - 15 Feb 2021
      • 1 Retweet
      • 2 Likes
      • kfunk937 aure
      1 reply 1 retweet 2 likes
        1. New conversation
        2. kfunk937‏ @kfunk937 Feb 16
          Replying to @GidMK @maureviv

          Maybe it's just me. But also, "standard therapy" seems to be poorly-defined, potentially quite heterogenous, dependent on patient progression +/- ICU +/- clinical judgement, especially wrt to dex: mentioned in text w/out further reference in analysis. Was it accounted for?pic.twitter.com/bybvLXx1gq

          1 reply 0 retweets 2 likes
        3. aure‏ @maureviv Feb 19
          Replying to @kfunk937 @GidMK

          aure Retweeted

          Now, that's wonderful news!! https://twitter.com/schneiderleonid/status/1362691728789147649?s=19 …

          aure added,

          This Tweet is unavailable.
          0 replies 0 retweets 2 likes
        4. End of conversation

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