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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
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@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK Feb 14

      Health Nerd Retweeted David Davis

      This vitamin D/COVID-19 study has gone viral, because the results appear to be impressive and people love promoting vitamin D Unfortunately, the study itself is...problematic Some peer-review on twitter 1/nhttps://twitter.com/DavidDavisMP/status/1360647462197878791 …

      Health Nerd added,

      David DavisVerified account @DavidDavisMP
      This is a very important study on vitamin D and Covid-19. Its findings are incredibly clear. An 80% reduction in need for ICU and a 60% reduction in deaths, simply by giving a very cheap and very safe therapy - calcifediol, or activated vitamin D. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3771318# …
      Show this thread
      51 replies 652 retweets 1,684 likes
      Show this thread
    2. Health Nerd‏Verified account @GidMK Feb 14

      2/n The study itself is here https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3771318 … At first glance, it appears to be a randomized controlled trial comparing calcifediol (vitamin D metabolite) to a control for severe COVID-19 with amazing outcomes (60% mortality reduction 👀)pic.twitter.com/CsaNlB69ZB

      1 reply 10 retweets 111 likes
      Show this thread
    3. Health Nerd‏Verified account @GidMK Feb 14

      3/n So, if you only glance at the abstract, you get the picture of an amazing positive result for vitamin D But reading further, the problems start almost immediately

      2 replies 15 retweets 118 likes
      Show this thread
    4. Health Nerd‏Verified account @GidMK Feb 14

      4/n Firstly, the study type. People are talking about this as "randomized" because the authors use that word in the abstract But the authors didn't actually randomize patients!pic.twitter.com/e5BVM9cLgC

      2 replies 16 retweets 158 likes
      Show this thread
    5. Health Nerd‏Verified account @GidMK Feb 14

      5/n What the authors describe doing is, depending on how you read it, either a cluster-randomized trial with a sample size of 8, or a completely uncontrolled observational trial I think it's almost certainly the latter

      3 replies 14 retweets 177 likes
      Show this thread
    6. Health Nerd‏Verified account @GidMK Feb 14

      6/n Why? Well, a big clue is that this is what the authors got ethics approval to do. Another clue is that nowhere in the study is an actual method for randomization described!pic.twitter.com/8kG103qNlG

      2 replies 12 retweets 153 likes
      Show this thread
    7. Health Nerd‏Verified account @GidMK Feb 14

      7/n If the authors did indeed do a randomized trial on participants who consented only to a cohort study, it is a decidedly non-trivial issue Where I live, there would be firings, lawsuits, and potentially criminal proceedings

      1 reply 10 retweets 157 likes
      Show this thread
    8. Health Nerd‏Verified account @GidMK Feb 14

      8/n More likely, in my opinion, is that this is simply as the authors describe an observational cohort study of people in hospital who were either given calcifediol or not. They just use the word randomize incorrectly

      2 replies 11 retweets 132 likes
      Show this thread
    9. Ken Maclean‏ @kenpcg Feb 14
      Replying to @GidMK

      how do journal editors let that slip through??? (Serious question)

      1 reply 0 retweets 0 likes
      Health Nerd‏Verified account @GidMK Feb 14
      Replying to @kenpcg

      It's a preprint!

      5:26 PM - 14 Feb 2021
      • 1 Like
      • Ken Maclean
      2 replies 0 retweets 1 like
        1. New conversation
        2. Damjan Vlastelica  💉 💉 😷 📉 📊 🎨 🖌️ 🇦🇺 🇷🇸 🇪🇺 🌍 🚴‏ @DamjanVlastelic Feb 14
          Replying to @GidMK @kenpcg

          Is there any argument for having media organizations regularly (@ least during the pandemic) report on content within a pre-print?

          1 reply 0 retweets 0 likes
        3. Ken Maclean‏ @kenpcg Feb 14
          Replying to @DamjanVlastelic @GidMK

          interesting thread on that from @liammannix in the last week w lots of good scicom responses

          0 replies 0 retweets 1 like
        4. End of conversation
        1. Ken Maclean‏ @kenpcg Feb 14
          Replying to @GidMK

          🤦‍♂️. Doubly unfortunate that is tacked it to the Lancet masthead.

          0 replies 0 retweets 0 likes
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