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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
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@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK Feb 14

      Health Nerd Retweeted Neil O'Leary

      14/n There's more. If this WAS indeed a cluster RCT (I'm skeptical), then the authors did the wrong analysis and the results are probably actually non-significant Excellent thread here:https://twitter.com/lycraolaoghaire/status/1360765704849481731?s=20 …

      Health Nerd added,

      Neil O'Leary @lycraolaoghaire
      A cluster-randomised trial with 5 wards in the treatment arm and 3 wards in the control arm. Only it's not described as such. Did they control for the correlation of outcomes within ward? https://twitter.com/DavidDavisMP/status/1360647462197878791 … pic.twitter.com/cHYBI9j4zc
      Show this thread
      2 replies 10 retweets 111 likes
      Show this thread
    2. Health Nerd‏Verified account @GidMK Feb 14

      Health Nerd Retweeted F. Perry Wilson, MD MSCE

      15/n There are also numerous issues I haven't covered that @fperrywilson does a great job dissecting here:https://twitter.com/fperrywilson/status/1360944814271979523?s=20 …

      Health Nerd added,

      F. Perry Wilson, MD MSCE @fperrywilson
      Folks, we need to talk about this Vitamin D trial. I have no stake in this game - take Vitamin D if you want but this pre-print is super sus. (THREAD) https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3771318 …
      Show this thread
      2 replies 11 retweets 107 likes
      Show this thread
    3. Health Nerd‏Verified account @GidMK Feb 14

      16/n There are other odd inconsistencies with the study. For example, they had 93 patients die and 110 ICU admissions That's a startlingly high ICU mortality rate, unless a majority of patients who died were not admitted to ICU

      3 replies 10 retweets 98 likes
      Show this thread
    4. Health Nerd‏Verified account @GidMK Feb 14

      17/n For some context, the average ICU mortality was about 30% in Spain at the time, which is still really high but not "almost 100%" highhttps://www.sciencedirect.com/science/article/abs/pii/S2341192920300986 …

      2 replies 6 retweets 80 likes
      Show this thread
    5. Health Nerd‏Verified account @GidMK Feb 14

      18/n The timelines are really weird. The study is reported as going for 91 days (1st March-31st May) but the K-M curves have 100 days for the treatment group. Probably a minor error, but still strangepic.twitter.com/SH9NKeiVgG

      2 replies 5 retweets 79 likes
      Show this thread
    6. Health Nerd‏Verified account @GidMK Feb 14

      19/n The K-M curves are also just bizarre. My guess is that they've confused the outcome death with the inverse for the second graph, but even then they really make little sense

      4 replies 5 retweets 75 likes
      Show this thread
    7. Health Nerd‏Verified account @GidMK Feb 14

      20/n Also, the study ran until May 31st. This magnificent, amazing, literally earth-shattering result (60% REDUCTION IN MORTALITY) took...8 months? And no news, barely any press, for a treatment that could save 60% of people with COVID-19?pic.twitter.com/UEwDfFLqB3

      2 replies 5 retweets 90 likes
      Show this thread
    8. Health Nerd‏Verified account @GidMK Feb 14

      21/n The study also wasn't pre-registered, which is an issue considering it started on March 1st 2020. When was the treatment protocol (HCQ+azithro and dexamethasone) decided on?pic.twitter.com/sRvMutWu9k

      1 reply 4 retweets 84 likes
      Show this thread
    9. Health Nerd‏Verified account @GidMK Feb 14

      22/n Also, how in the world did one relatively modest-sized hospital have 8 fully-dedicated COVID-19 wards open in Barcelona, at a time when Spain itself only had a handful of COVID-19 cases? Any Barcelonian followers who can elaborate?

      6 replies 5 retweets 97 likes
      Show this thread
    10. Health Nerd‏Verified account @GidMK Feb 14

      23/n The same author group wrote another paper on the same patient population in January. Why was there no mention of this trial, or the MASSIVE mortality reduction anywhere? None of this is necessarily disqualifying, it's just really odd!pic.twitter.com/n6J8ihD9S3

      1 reply 4 retweets 78 likes
      Show this thread
      Health Nerd‏Verified account @GidMK Feb 14

      24/n I should specify that none of this makes the study totally sketchy, it's just all really weird and they are things that the authors should have explained in the paper

      3:49 PM - 14 Feb 2021
      • 2 Retweets
      • 58 Likes
      • Knight in rusty armour John Gerardo Perrotta Randolf Richardson 張文道 🇨🇦 Rachael Priddle Former 90s kid. Deliberate Dendrite 🎩🎃Nervardia has excellent 5G reception💉💉 Peter den Haan
      2 replies 2 retweets 58 likes
        1. New conversation
        2. Health Nerd‏Verified account @GidMK Feb 14

          25/n Overall, what we have is a study that, if run as specified, was a non-randomized prospective cohort study that gives us very little/no new information on vitamin D for COVID-19

          2 replies 6 retweets 81 likes
          Show this thread
        3. Health Nerd‏Verified account @GidMK Feb 14

          26/n This doesn't mean that you shouldn't take vitamin D, it's relatively low-cost and the harm is mostly to your wallet, but the jury is still out whether it will have any benefit at all to COVID-19 🤷‍♂️

          10 replies 12 retweets 128 likes
          Show this thread
        4. Health Nerd‏Verified account @GidMK Feb 15

          27/n Update: the authors have confirmed that this was not a randomized trial on PubPeer. They are still using the word "random" in a very confusing way, but what is described here is not an RCT by any descriptionpic.twitter.com/epHN075OA7

          2 replies 6 retweets 47 likes
          Show this thread
        5. Health Nerd‏Verified account @GidMK Feb 15

          28/n And I wrote a piece about this trial and COVID-19 and vitamin D in generalhttps://gidmk.medium.com/vitamin-d-and-covid-19-an-update-59fb2f9cceb5 …

          5 replies 12 retweets 53 likes
          Show this thread
        6. End of conversation
        1. Jennifer K  😷‏ @Jennifer_inLR Jun 16
          Replying to @GidMK

          I’m just confused. How is this in The Lancet at all?

          0 replies 0 retweets 1 like
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