9/n But even then, there are massive issues For example, the PRIMARY ANALYSIS (60% mortality reduction) excludes ~20% of their total sample because of missing baseline data on vitamin D statuspic.twitter.com/jPDvuCHBrZ
Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him
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9/n But even then, there are massive issues For example, the PRIMARY ANALYSIS (60% mortality reduction) excludes ~20% of their total sample because of missing baseline data on vitamin D statuspic.twitter.com/jPDvuCHBrZ
10/n And we get no information whatsoever on these missing people. Were they from the treated group? The control? Did they die, go to ICU etc? We have no idea!
11/n Another issue is that there were 8 presumably quite different COVID-19 wards, but the authors basically ignore these differences. There is no discussion of the purpose of the wards, and no correction for it in the statistical model
12/n Could the results be explained by different wards having different admissions protocols? Potentially, but we are given no information to make this assessment at all
13/n This is even more troubling when you consider that the baseline vitamin D levels are different in the treated and control patients (for whom there was vit D information) So we know that the wards were different, but we don't know how much or whypic.twitter.com/Zr4TFceOOE
Health Nerd Retweeted Neil O'Leary
14/n There's more. If this WAS indeed a cluster RCT (I'm skeptical), then the authors did the wrong analysis and the results are probably actually non-significant Excellent thread here:https://twitter.com/lycraolaoghaire/status/1360765704849481731?s=20 …
Health Nerd added,
Health Nerd Retweeted F. Perry Wilson, MD MSCE
15/n There are also numerous issues I haven't covered that @fperrywilson does a great job dissecting here:https://twitter.com/fperrywilson/status/1360944814271979523?s=20 …
Health Nerd added,
16/n There are other odd inconsistencies with the study. For example, they had 93 patients die and 110 ICU admissions That's a startlingly high ICU mortality rate, unless a majority of patients who died were not admitted to ICU
17/n For some context, the average ICU mortality was about 30% in Spain at the time, which is still really high but not "almost 100%" highhttps://www.sciencedirect.com/science/article/abs/pii/S2341192920300986 …
Thanks for the info. Are you against supplementing vitamin D? If so, why?
I have no particularly strong opinions about supplementing vit D. Do it if you want, the harms are relatively minimal and mostly confined to your wallet
What do you think about Examine? They suggest that ppl should supplement with vitamin d if they don't have optimal levels.
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