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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. ice9‏ @__ice9 15 Dec 2020
      Replying to @GidMK

      ice9 Retweeted ice9

      I think that is a very absolutist view. EBM is important. EBM purity spirals are harmful.https://twitter.com/__ice9/status/1328856819742232576?s=19 …

      ice9 added,

      ice9 @__ice9
      Replying to @__ice9 @alt_kia
      Somehow the ideas that empirical evidence should guide health decisions, and that higher quality evidence is better, were short-circuited into doing nothing at all while awaiting perfect evidence that will never come.
      1 reply 0 retweets 0 likes
    2. Health Nerd‏Verified account @GidMK 15 Dec 2020
      Replying to @__ice9

      There is a complex equation that includes a very careful evaluation of the evidence at hand to guide decision-making. But when the best evidence is truly woeful, the only real conclusion you can make is that you don't know enough to make a decision

      1 reply 0 retweets 0 likes
    3. ice9‏ @__ice9 15 Dec 2020
      Replying to @GidMK

      I do not believe the matter has advanced to such precise quantifiability as that implied here. Regardless, acting on uncertain information and making due consideration for cost-benefit trade-offs are universal practical requirements in any empirical discipline.

      1 reply 0 retweets 2 likes
    4. Health Nerd‏Verified account @GidMK 15 Dec 2020
      Replying to @__ice9

      The issue is that we want to know the answer to the question "does ivermectin help for COVID-19?". Currently, the evidence does not allow us to answer that question

      3 replies 0 retweets 0 likes
    5. ice9‏ @__ice9 15 Dec 2020
      Replying to @GidMK

      I dispute that insufficient evidence is available to assess the question.

      1 reply 0 retweets 1 like
    6. Health Nerd‏Verified account @GidMK 15 Dec 2020
      Replying to @__ice9

      Oh, so there is a good RCT?

      1 reply 0 retweets 0 likes
    7. ice9‏ @__ice9 15 Dec 2020
      Replying to @GidMK

      There have been many RCTs of various levels of quality. I wrote at the very onset that it would be pointless to address only a single one. Here is a realtime summary: https://covid19criticalcare.com/flccc-ivermectin-summary/ … Here is a broader discussion paper, likewise updated to match: https://covid19criticalcare.com/flccc-ivermectin-in-the-prophylaxis-and-treatment-of-covid-19/ …

      1 reply 0 retweets 0 likes
    8. Health Nerd‏Verified account @GidMK 15 Dec 2020
      Replying to @__ice9

      Well, I have actually had a read of the first of those and even from a brief skim it appears to mischaracterize observational evidence as RCTs and not adequately represent the state of the evidence

      2 replies 0 retweets 0 likes
    9. ice9‏ @__ice9 15 Dec 2020
      Replying to @GidMK

      The summary is not limited to RCTs. I was trying to provide a reference to the overall state of clinical literature on ivermectin in COVID-19. If you noticed above, I already argued against considering most observational studies.

      2 replies 0 retweets 0 likes
    10. ice9‏ @__ice9 15 Dec 2020
      Replying to @__ice9 @GidMK

      ice9 Retweeted ice9

      Either way, a single trial cannot address all stages of the disease, all patient populations, and all existing baseline standards of care. https://twitter.com/__ice9/status/1334600863533457410?s=19 … It is important to consider the context for each.

      ice9 added,

      ice9 @__ice9
      People want ironclad proof for everything. It doesn't exist. It never will. Even the best trials only apply to a certain stage of the disease in a certain set of the population at a certain dose with a certain baseline standard of care.
      Show this thread
      1 reply 0 retweets 0 likes
      Health Nerd‏Verified account @GidMK 15 Dec 2020
      Replying to @__ice9

      Honestly, this is getting tiresome. Ironclad proof is a complete strawman, my point is that the evidence is not sufficient to come to even the most basic of reasonable conclusions. Linking to the same awful research over and over does not change this

      3:44 AM - 15 Dec 2020
      1 reply 0 retweets 0 likes
        1. ice9‏ @__ice9 15 Dec 2020
          Replying to @GidMK

          Then explain why it is awful. I did much more than provide links. Pick an RCT with a mortality endpoint and tell me why it tells us nothing at all, in your opinion.

          0 replies 1 retweet 5 likes
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