Interesting titbit from the Pfizer study - the attack rate in the general population and the people who had already had COVID-19 was similar. 1.3% of people who had COVID-19 antibodies BEFORE vaccination got infectedpic.twitter.com/c4rJ8TGQn5
Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him
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Interesting titbit from the Pfizer study - the attack rate in the general population and the people who had already had COVID-19 was similar. 1.3% of people who had COVID-19 antibodies BEFORE vaccination got infectedpic.twitter.com/c4rJ8TGQn5
The main take-home from this is that people who have already had COVID-19 will probably benefit from vaccination, although it is interesting to note the high rate of 'reinfections' here (maybe people who were sick but asymptomatic at enrolment?)
It seems like one would want to see the case accumulation curves to assess this. If most cases weren't already present pre-symptomatically at enrollment, wouldn't it indicate that previous infection provided no protection from symptomatic COVID-19?
That's an interesting question. From a study design point of view, it's a selected subgroup so hard to interpret, and it could potentially also be due to their case definition? If someone was recently infected but still PCR positive?
But they'd have to report new symptoms after study start and have residual RNA. The odds of that occurring at same attack rate as people w/out previous exposure seems low, no?
Yeh it is a bit odd. I'm not sure what to make of it either
So, I reread that paragraph very carefully and it says that only 1 of these cases occurred 7 days or more after the completion of the vaccination regimen. So, 18 people PCR +ve and symptomatic <28 days after being vaccinated when they were confirmed asymptomatic
And 1 person who was PCR +ve >28 days later. I think your earlier point becomes even more important - if these PCR +ves were mostly days after the first shot, you'd assume they were actually infected before the trial I think?
Another point! We don't know if the serology was test-adjusted, and they appear to have run IgG and IgM (as per the protocol). Possible that some of these are false +ves, we really need a lot more info on the group
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