For those who are interested, the largest clinical trial to date has thus far not shown a benefit for vitamin D supplementation to treat severe COVID-19https://www.medrxiv.org/content/10.1101/2020.11.16.20232397v1 …
The dose almost completely corrected serum vitamin D deficiency so that argument makes no sense eitherpic.twitter.com/EZjO2M6EkL
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Doesn't it take a while to metabolize Vit D into calcifediol? Is a correct Vit D serum level equivalent to sufficient calcifediol? I would imagine the answer depends on when the Vit D serum level is measured, no?
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I’m still waiting for a scientific explanation as to why this 2008 study proving similar CoV(229E) MUCH more virulent against low G6PD cells has not been investigated w/Covid19 (& VitD links w/G6PD)https://academic.oup.com/jid/article/197/6/812/919467 …
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Serum levels might not fully indicate Vit D that’s linked with G6PD in cells of tissues to produce NADPH needed for T3 production, antimicrobial defense, Hb recovery, & cell membranes protection.
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I mean, perhaps, but they do indicate systemic uptake so it still makes little sense to argue that the dose didn't work to correct vitamin D deficiency
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Not sure why you keep using the term “argue” & “argument” - but those who most understand the important role of Vitamin D have never ‘argued’ serum level in & of itself is the only determinant. The point is to reach the cells. Calcifediol might be necessary
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