For those who are interested, the largest clinical trial to date has thus far not shown a benefit for vitamin D supplementation to treat severe COVID-19https://www.medrxiv.org/content/10.1101/2020.11.16.20232397v1 …
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I believe the rationale is that a higher dose is unlikely to cause negative issues but will correct the deficiency more quickly (and thus improve outcomes)
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But high doses of the form in these trials -cholecalciferol - have been known to shut down receptors. Wish they would use calcifediol like the Spanish trial. If I had a loved one hospitalized for Covid, I’d ask for it.
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Interesting that it almost seems they purposely used form & dosage to try to make sure it didn’t work - rather than use same form & dosage from the trial that had excellent results. Why not a large trial w/calcifediol in same dosages as Spanish trial??
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While the trials were published months apart, they started recruiting within a few weeks of each other. The Spanish trial only published their results on 29 August, while the Brazilian study started on 2 June
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