For those who are interested, the largest clinical trial to date has thus far not shown a benefit for vitamin D supplementation to treat severe COVID-19https://www.medrxiv.org/content/10.1101/2020.11.16.20232397v1 …
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That being said, the study looks impressively solid, and this is some truly beautiful honesty wrt sample sizepic.twitter.com/M0Po8QNANd
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The only very minor criticism I have of this research is that the sensitivity analysis used a Bonferroni correction for multiple comparisons, which you could argue is a bit too blunt and may bias towards the null. That being said, it doesn't change the main results anyway so...ehpic.twitter.com/zSCnQObg98
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Main results are here - no benefit from vitamin D for hospital stay duration, death, ICU likelihood, or duration of mechanical ventilation Pretty much no impact whatsoeverpic.twitter.com/ERGXKl2TCf
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