This is actually an excellent point that is not made often enough. Most vaccine trials are done over years, so they have smaller numbers because more people get infected. The COVID-19 trials are VASThttps://twitter.com/dfreedman7/status/1331699376419459072 …
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We won't pick up on any long-term side-effects that only take place after 6-12 months, of course, because of the shorter time frame Still, the trials are pretty amazing
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Worth noting here that when I say "long-term" I really mean "only diagnosed after 6 months". By the time vaccines are rolled out, we'll have at least 6 months of follow-up data so anything that you'd expect to be picked up in that time-frame should show some signal
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The real worry is chronic diseases that take years to be diagnosed, but that's not the same as serious chronic issues that start immediately after vaccination (which is what people often worry about)
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And this sort of problem tends to be incredibly rare in terms of vaccines. I actually can't think off the top of my head of an example, although I'm sure they exist. Anyone?
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Replying to @cherryblack
Guess it depends on whether they are diagnosed pre or post birth. If the former, they'd probably be picked up in time
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Replying to @GidMK
Trying to remember a lecture from years ago about a vaccine from the 80s and pregnancy. I can’t remember if it was avoided as a precaution or because of known issues. Brain not working this morning.
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Well, most live vaccines are contraindicated for pregnancy because of the potential to cause issues, but I can't remember a specific example that's been demonstrated 
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Replying to @GidMK
Yeah, I feel like a lot of the precautions are due to “possible” harm rather than actual. Which is great, but it does leave everything a bit vague.
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