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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
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@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    Health Nerd‏Verified account @GidMK 25 Nov 2020

    Health Nerd Retweeted Dan Freedman, DO

    This is actually an excellent point that is not made often enough. Most vaccine trials are done over years, so they have smaller numbers because more people get infected. The COVID-19 trials are VASThttps://twitter.com/dfreedman7/status/1331699376419459072 …

    Health Nerd added,

    Dan Freedman, DO @dfreedman7
    I cannot emphasize enough that the phase 3 trials for the mRNA vaccines having 30k (moderna) & 44k (pfizer) subjects are huge trials. Having zero severe adverse events so far in both trials is very reassuring. https://twitter.com/dfreedman7/status/1331694829328281603 …
    12:53 PM - 25 Nov 2020
    • 42 Retweets
    • 184 Likes
    • Heather grollen Max Maydanchik Sock👁️‍🗨️🧦 Garf Carmina Sally P James Van Dyke Laura Zukiwsky
    7 replies 42 retweets 184 likes
      1. New conversation
      2. Health Nerd‏Verified account @GidMK 25 Nov 2020

        We won't pick up on any long-term side-effects that only take place after 6-12 months, of course, because of the shorter time frame Still, the trials are pretty amazing

        4 replies 4 retweets 36 likes
        Show this thread
      3. Health Nerd‏Verified account @GidMK 25 Nov 2020

        Worth noting here that when I say "long-term" I really mean "only diagnosed after 6 months". By the time vaccines are rolled out, we'll have at least 6 months of follow-up data so anything that you'd expect to be picked up in that time-frame should show some signal

        3 replies 1 retweet 23 likes
        Show this thread
      4. Health Nerd‏Verified account @GidMK 25 Nov 2020

        The real worry is chronic diseases that take years to be diagnosed, but that's not the same as serious chronic issues that start immediately after vaccination (which is what people often worry about)

        2 replies 1 retweet 31 likes
        Show this thread
      5. Health Nerd‏Verified account @GidMK 25 Nov 2020

        And this sort of problem tends to be incredibly rare in terms of vaccines. I actually can't think off the top of my head of an example, although I'm sure they exist. Anyone?

        10 replies 1 retweet 22 likes
        Show this thread
      6. End of conversation
      1. New conversation
      2. Ioannis Kontoyiannis‏ @yiannis_entropy 25 Nov 2020
        Replying to @GidMK

        It's very reassuring indeed, that there are no adverse effects IN THIS TIME FRAME of 3-6 months. Mos vaccine trials are done over years in part in order to follow participants over years!

        1 reply 0 retweets 2 likes
      3. Riff Schott-Skjerven  🛵 🧮 🌲‏ @RiffSkjerven 25 Nov 2020
        Replying to @yiannis_entropy @GidMK

        Riff Schott-Skjerven  🛵 🧮 🌲 Retweeted R Marcucio

        https://twitter.com/mcfunny/status/1331699460393500672?s=20 …

        Riff Schott-Skjerven  🛵 🧮 🌲 added,

        R Marcucio @mcfunny
        Replying to @dfreedman7 @CreateAccYour1
        I was just at a grand rounds and Paul Offit was discussing vaccine safety. he made the comment that the most/all known vaccine reactions occur within 28 days of the vaccination. these trials are longer than that
        1 reply 0 retweets 2 likes
      4. End of conversation
      1. New conversation
      2. מאיר רובין Meir Rubin‏ @Meir_Rubin 25 Nov 2020
        Replying to @GidMK

        Yep. But what about possible long term side effects? Size do not solve them.

        1 reply 0 retweets 2 likes
      3. Health Nerd‏Verified account @GidMK 25 Nov 2020
        Replying to @Meir_Rubin

        Was just writing the second tweet that said this 😂

        0 replies 0 retweets 3 likes
      4. End of conversation
      1. Jin Russell‏ @DrJinRussell 25 Nov 2020
        Replying to @GidMK

        Great point. Speed in reporting results is also in part due to rampant Covid-19 community transmission in trial locations

        0 replies 0 retweets 2 likes
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      1. New conversation
      2. John Parkes‏ @DrJohnParkes 25 Nov 2020
        Replying to @GidMK

        I wonder how many adverse reactions you would expect as a background rate naturally say per 10K or whatever is a resonable denominator?

        2 replies 0 retweets 0 likes
      3. Brendan‏ @BrendanL2011 1 Dec 2020
        Replying to @DrJohnParkes @GidMK

        Do you mean adverse events or adverse reactions?

        1 reply 0 retweets 0 likes
      4. Show replies

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