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Replying to @maureenchuck1 @MackayIM
These are all preliminary analyses - the studies all need more cases to be powered for their main effect, what we know from these analyses is that the studies should continue because a benefit is likely (more complex, but that's the gist)
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From working in clinical trials the exact number of cases needed is usually a hugely guarded secret only known to a few intil the trial is over or has been stopped. One trial I worked on was for a SERM that would reduce the incidence of breast cancer.
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They stopped the study about 12 months early when it became clear that they weren't going to get the number of breast cancer cases needed to be able to prove that.
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Replying to @maureenchuck1 @MackayIM
These trials are hugely public, which is actually great for science and all of us. You can read the entire protocol (including the exact number of cases needed) online for all of them
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Do you have a link to them?
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Here's the Pfizer one, don't have time to hunt down Moderna rn https://pfe-pfizercom-d8-prod.s3.amazonaws.com/2020-09/C4591001_Clinical_Protocol.pdf …
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