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From working in clinical trials the exact number of cases needed is usually a hugely guarded secret only known to a few intil the trial is over or has been stopped. One trial I worked on was for a SERM that would reduce the incidence of breast cancer.
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They stopped the study about 12 months early when it became clear that they weren't going to get the number of breast cancer cases needed to be able to prove that.
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Exactly, I'm always mindful of what happened to the anti-inflammatory Vioxx, a competitor to Celebrex. It was only after millions of doses had been administered that death from cardiovascular effects became significant & the drug was withdrawn worldwide.
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I was working at Merck when that happened.
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This "powered for" thing. Is that new? Specific episode jargon?
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No its a statistical test used to determine sample size for a study.https://emj.bmj.com/content/20/5/453?__cf_chl_jschl_tk__=e94d26294551aa12770bf582ce70c75cfb57ded2-1605738512-0-AdU2CXMpU3m3SNuJRlvFd4MQdDBy15v1vdn2beRaa6VseFXbrG2WVkw0CM_2cff3Rj3lAH0_ymBhVsJw4-LpO7Hvef-mz7zNpNakt9C9Yeq9i204hDM5uSzK13ud0Tq3-f0NejMgpTq5fCePQf5oinXg8PTN7C-jc9eyuhIeQXrZDpYhcEF_Y_7I1zJLn2BqCWKZ0zvMWV3H8QDT8Sp8qosPdrTun52vBJ4Pcye1t9WHohg1JR44NxbGHT1XJoPTy8WGVA6XFV9ornBqkMvPitrdzRCt8D12fk0z0AhEgtRPCjBt9sYVdPG_l75HzXPkjvpyAibqQx7uzfEfLFOfkaA …
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