@virtahealth and others could potentially fund and run such a trial yeah?
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Replying to @DrNadolsky @davidludwigmd and
Yeh wow that review mostly seems to show that the evidence is of extremely low qualitypic.twitter.com/TWNx9XHZTu
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Replying to @GidMK @DrNadolsky and
Wow, I do not agree with the conclusions here. All of the studies were at high risk of bias, heterogeneity was a big issue, half of the included patients were from a non-randomized trial, and there was no publication bias assessment...pic.twitter.com/gB3hSCx0oH
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Replying to @GidMK @DrNadolsky and
That's why we need some big, long-term, multi-center rigorous trials ... like we had for low-fat diets (e.g, Look Ahead, Women's Health Initiative clinical trial).
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Replying to @davidludwigmd @DrNadolsky and
Sure, let's do more research, but this review is about as meaningless as research gets. I don't think you can reasonably conclude anything at all about ketogenic diets for diabetes from this
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Replying to @GidMK @DrNadolsky and
You raise important concerns worth investigating. If the meta-analysis is wrong, it should be corrected (or withdrawn). However, knowing most of the original lit, I think effect sizes are probably in the right ballpark, and broadly consistent with other MAhttps://pubmed.ncbi.nlm.nih.gov/23651522/
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I mean, they literally didn't compare weight loss or changes in HbA1c etc across trials. They aggregated the post values. It's not consistent with previous lit at all because it's a meaningless analysis that no one else has done
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Replying to @GidMK @DrNadolsky and
Based on the discrepancy you found in your quick re-analysis, and the admittedly inadequate methods section, I'll delete my post on this MA.
0 replies 0 retweets 2 likesThanks. Twitter will use this to make your timeline better. UndoUndo
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