@virtahealth and others could potentially fund and run such a trial yeah?
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You raise important concerns worth investigating. If the meta-analysis is wrong, it should be corrected (or withdrawn). However, knowing most of the original lit, I think effect sizes are probably in the right ballpark, and broadly consistent with other MAhttps://pubmed.ncbi.nlm.nih.gov/23651522/
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I mean, they literally didn't compare weight loss or changes in HbA1c etc across trials. They aggregated the post values. It's not consistent with previous lit at all because it's a meaningless analysis that no one else has done
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