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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
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@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Dr Vyom Sharma (ethnic mum)‏ @drvyom 10 Nov 2020

      Dr Vyom Sharma (ethnic mum) Retweeted Health Nerd

      important piece re: pfizer vaccine.https://twitter.com/GidMK/status/1326304265304903680 …

      Dr Vyom Sharma (ethnic mum) added,

      Health NerdVerified account @GidMK
      An interim analysis showed 90% efficacy for a COVID-19 vaccine I wrote about what that means for all of us ping @MackayIM @TheSciBabe https://coronavirus.medium.com/an-epidemiologist-on-what-to-expect-from-a-covid-19-vaccine-c727f4bf32dc …
      3 replies 5 retweets 26 likes
    2. Hilda Bastian, PhD‏ @hildabast 10 Nov 2020
      Replying to @drvyom

      @gidmk Too many things to correct, but a few things: the trial isn't at less half recruited - it might even be fully recruited. Original interim events wasn't 64: they were 32, 62, 92, 120. 94 infections weren't across the study - only Covid-free people 7 days after 2nd shot..1/2pic.twitter.com/MNykMegaix

      2 replies 0 retweets 1 like
    3. Health Nerd‏Verified account @GidMK 10 Nov 2020
      Replying to @hildabast @drvyom

      Oh yep I should correct the 64 typo! Fully recruited possibly, but I didn't say half just that it wasn't done yet. I do specify the 28-day timepoint and the three week schedule so I'm confused about that?

      1 reply 0 retweets 0 likes
    4. Hilda Bastian, PhD‏ @hildabast 10 Nov 2020
      Replying to @GidMK @drvyom

      (1) It's not just a typo - 62 wasn't the original first interim analysis. (2) You did ⬇️ (3) 7+ days after 2nd shot isn't exactly the same as 28-days (unspecified) & it's still not restricted to the people who were known to be Covid-free.pic.twitter.com/JjwgwMGxau

      1 reply 0 retweets 0 likes
    5. Health Nerd‏Verified account @GidMK 10 Nov 2020
      Replying to @hildabast @drvyom

      I'm not sure I'd agree that's an error as such, I was more focused on the meaning of such an analysis to people rather than the discussion with the FDA about the initially planned interim analysis. I don't see where I say half? I'm very confused?

      2 replies 0 retweets 1 like
    6. Health Nerd‏Verified account @GidMK 10 Nov 2020
      Replying to @GidMK @hildabast @drvyom

      And I did say: first shot 0 days, second shot 21 days, primary endpoint 28 days. You're right that I didn't go into the serological and other screenings at the start of the study to exclude people with previous COVID-19, but honestly I thought it was implied. My mistake!pic.twitter.com/DaOgsvND3K

      1 reply 0 retweets 0 likes
    7. Hilda Bastian, PhD‏ @hildabast 10 Nov 2020
      Replying to @GidMK @drvyom

      It's not implied: that's why it was specified in the press release. It wasn't an exclusion criterion because they have to show it's safe for people who've already had Covid-19 without knowing it. See the protocolpic.twitter.com/bdSdVZOyYQ

      1 reply 0 retweets 2 likes
    8. Health Nerd‏Verified account @GidMK 10 Nov 2020
      Replying to @hildabast @drvyom

      Sorry, you're right - I was thinking about people with symptomatic disease

      1 reply 0 retweets 2 likes
    9. Hilda Bastian, PhD‏ @hildabast 10 Nov 2020
      Replying to @GidMK @drvyom

      ?? Sorry, that doesn't make sense since it wasn't an exclusion criterion & differentiating between these people is a high-level objective of the trial.

      1 reply 0 retweets 0 likes
      Health Nerd‏Verified account @GidMK 10 Nov 2020
      Replying to @hildabast @drvyom

      Wait now I'm confusing myself. The exclusion criteria specify that people with previous COVID-19 are not included in the studypic.twitter.com/ltxMvjIURJ

      6:04 PM - 10 Nov 2020
      • 1 Like
      • Dr Vyom Sharma (ethnic mum)
      1 reply 0 retweets 1 like
        1. New conversation
        2. Hilda Bastian, PhD‏ @hildabast 10 Nov 2020
          Replying to @GidMK @drvyom

          Yes, from the way you described it. (Need to spend more time with the protocol.)

          1 reply 0 retweets 0 likes
        3. Health Nerd‏Verified account @GidMK 10 Nov 2020
          Replying to @hildabast @drvyom

          Protocol is somewhat unclear tbh. People with current infections definitely 'delayed' recruitment until they got better. Exclusion criteria also quite specific. But as you point out, this seems in conflict with the specified outcomes unless 'infection' does not mean COVID-19

          1 reply 0 retweets 1 like
        4. Show replies

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