This is incorrect. Given that low severity cases have been modelled to be the driving force behind the pandemic, reducing/eliminating those would be of enormous benefit
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Replying to @camstreet1 @igoreckert1
Sure, but this is in the context of HCQ as a prophylactic. If it prevented mild disease, it could be an incredibly important finding even if it did not reduce hospitalizations
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Replying to @camstreet1 @igoreckert1
It absolutely is a claim made for HCQ. The moving goalposts of how exactly HCQ 'works' has been really quite funny to watch
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Replying to @camstreet1 @igoreckert1
Mechanisms maybe not, but claims about disease yes definitely. Back in March we were discussing whether the drug should be given to hospitalised patients, now since it doesn't work for any indication tested so far the claims have become ridiculously specific
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I mean, it doesn't work to prevent disease in any context, doesn't prevent progression from mild->severe disease, doesn't improve outcomes of severe disease...but it does prevent a subset of infections from becoming serious? Do you think that's likely?
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It wasn't underpowered, it was monumentally inadequate to answer the question. We now have adequate studies and they are universally null
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