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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Alastair McAlpine, MD‏Verified account @AlastairMcA30 7 Oct 2020
      Replying to @davideyoungmd @MarkHoofnagle @gorskon

      I don’t share your remdesivir optimism. Why has Gilead not released the proper 28 day results? Why did they compare the treatment group to an ‘historical cohort’? I understand people using it, but let’s agree the evidence is THIN.

      1 reply 1 retweet 1 like
    2. David Young‏ @davideyoungmd 7 Oct 2020
      Replying to @AlastairMcA30 @MarkHoofnagle @gorskon

      The pivotal study was published in the NEJM. Is this the study that you are criticizing? It was a double blinded randomized study. They did not compare to a historical cohort.https://www.nejm.org/doi/full/10.1056/NEJMoa2007764 …

      2 replies 0 retweets 0 likes
    3. Alastair McAlpine, MD‏Verified account @AlastairMcA30 7 Oct 2020
      Replying to @davideyoungmd @MarkHoofnagle @gorskon

      Yeah- this is the preliminary report. Not all the patients were at 28 days yet. Where is that data? As far as I recall, Gilead never released it and instead compared it to an ‘historical cohort’.pic.twitter.com/uUSSjJBFLa

      2 replies 0 retweets 2 likes
    4. David Young‏ @davideyoungmd 7 Oct 2020
      Replying to @AlastairMcA30 @MarkHoofnagle @gorskon

      Which study is this? The study that I refer to is https://www.nejm.org/doi/full/10.1056/NEJMoa2007764 … number: NCT04280705. It is this study that earned the emergency approval. Is this the study that you are referring to?

      2 replies 0 retweets 0 likes
    5. Alastair McAlpine, MD‏Verified account @AlastairMcA30 7 Oct 2020
      Replying to @davideyoungmd @MarkHoofnagle @gorskon

      Screenshot is taken from your study.

      1 reply 0 retweets 1 like
    6. Alastair McAlpine, MD‏Verified account @AlastairMcA30 7 Oct 2020
      Replying to @AlastairMcA30 @davideyoungmd and

      And if I’m not mistaken, we never got the full data. Gilead released some gobbledygook about comparisons with ‘standard of care’, but we never saw the completed data for the study above at 28 days. And you better believe if it was good, Gilead woulda sung it from the rooftops.

      1 reply 0 retweets 1 like
    7. Alastair McAlpine, MD‏Verified account @AlastairMcA30 7 Oct 2020
      Replying to @AlastairMcA30 @davideyoungmd and

      https://www.gilead.com/news-and-press/press-room/press-releases/2020/7/gilead-presents-additional-data-on-investigational-antiviral-remdesivir-for-the-treatment-of-covid-19 …

      1 reply 0 retweets 0 likes
    8. Mark Hoofnagle‏ @MarkHoofnagle 7 Oct 2020
      Replying to @AlastairMcA30 @davideyoungmd @gorskon

      Yeah. Press release science. Not loving it.

      1 reply 0 retweets 3 likes
    9. Health Nerd‏Verified account @GidMK 7 Oct 2020
      Replying to @MarkHoofnagle @AlastairMcA30 and

      Health Nerd Retweeted mike johansen

      Especially when later investigations find that there may be no benefit to mortalityhttps://twitter.com/mikejohansenmd/status/1310898886819667968?s=20 …

      Health Nerd added,

      mike johansen @mikejohansenmd
      Updated Remdesivir Meta-analysis on 28 Day Mortality Version 3. (Others linked below) #twitter_meta_analysis Methods: Stata 15 (factory settings) Systematic Review: See Supplement Data: 3 trials Peer-review: improvement to many recent efforts Theme: Bland pic.twitter.com/paboR3bbDP
      Show this thread
      2 replies 0 retweets 5 likes
    10. Mark Hoofnagle‏ @MarkHoofnagle 7 Oct 2020
      Replying to @GidMK @AlastairMcA30 and

      Oof. @gidmk has spoken. Thanks man, you’re the best of epitwitter.

      1 reply 0 retweets 4 likes
      Health Nerd‏Verified account @GidMK 7 Oct 2020
      Replying to @MarkHoofnagle @AlastairMcA30 and

      Blame @mikejohansenmd for this one, I haven't checked the numbers myself and there may be other studies out there!

      4:23 PM - 7 Oct 2020
      • 2 Likes
      • mike johansen Mark Hoofnagle
      1 reply 0 retweets 2 likes
        1. Mark Hoofnagle‏ @MarkHoofnagle 7 Oct 2020
          Replying to @GidMK @AlastairMcA30 and

          Pretty standard regression to the mean, and the only positive data coming from the press release version...i repeat, shenanigans.

          0 replies 0 retweets 1 like
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