Gotta love the "without serious side effects" as if they NEVER happened rather than that they were very rare
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I actually think that a relative risk reduction of 20% would, in most cases, make HCQ completely useless for PrEP. You'd need continuous, daily use of the drug in the entire population for an absolute risk difference in prevalence of COVID-19 of about 1%
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Oh god, even the term 'stratified lockdown' is cringe-worthy. Do what we did here in NSW and have a 300+ person team of contact tracers plus massive testing capacity and isolation of travelers etc
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Tell them that we are less restricted than Sweden (by far) and this week <5 cases of local transmission. They'll come around
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Replying to @GidMK
mike johansen Retweeted mike johansen
The negativity of this thread is kinda silly. My analysis show potential.https://mobile.twitter.com/mikejohansenmd/status/1311414567352913920 …
mike johansen added,
mike johansen @mikejohansenmdI'm gonna do some advanced math for a 20% reduction in getting CoViD: Mortality rate: 0.1% (rough estimate) Risk of contacting: 10% per year (very rough estimate) Reducation in contracting: 20% 0.1*0.001=0.0001 0.08* 0.001= 0.00008 Net benefit = 0.00002 pic.twitter.com/1QH6USH2U5Show this thread1 reply 0 retweets 2 likes
Well, this meta-analysis suggests an 0.2% increase in absolute risk of cardiovascular events for long-term HCQ use so it'd be ~100 cardiovascular events caused for every life saved there too!https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(20)30276-9/fulltext#tbl2 …
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