If you run dozens of studies that are all flawed, most of them in the same ways, then you haven't gotten any closer to an answer to your original question. It's a pretty foundational fact of research
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Replying to @GidMK @Rootclaim
If the flaws are uncorrelated then the probability that all the results are due to flaws approach zero as you add studies.
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Replying to @saarwilf @Rootclaim
That's simply not true, and a misunderstanding of how scientific evidence works. I'd suggest reading the Cochrane handbook to get a better handle on evidence appraisal (it is, unfortunately, very dense)
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Replying to @GidMK @Rootclaim
I guess the point where someone on the Internet tries to educate me about my area of expertise is where I bow out, and offer you to back your confidence with actions: https://blog.rootclaim.com/treating-covid-19-with-vitamin-d-100000-challenge/ … Good night sir.
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Replying to @saarwilf @Rootclaim
Lol. Even if I had $100,000 to throw away, it seems like a garish publicity stunt to me. If you want to actually do some good, put the money towards a study on Vitamin D and I'll happily throw in my consulting services for free
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Replying to @GidMK @Rootclaim
These are not mutually exclusive. I'm also funding a clinical trial.
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Replying to @saarwilf @Rootclaim
That's great! Probably a much more useful intervention than a bet that won't be resolved until it doesn't really matter anyway (and would probably just result in a legal battle due to the vague wording)
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Replying to @GidMK @Rootclaim
The purpose of the bet is not to make a profit but to accelerate rational discussion. People become much more critical when they risk something.
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Replying to @saarwilf @Rootclaim
Nah, it's just a pointless dichotomization. I wouldn't take the bet because the evidence ISN'T THERE - I'm not saying vit D is useless, but that we have no idea if it works or not. Also, most of the experts are (like me) unable to easily proffer $100,000 in assets for silly bets
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Replying to @GidMK @Rootclaim
That's explained in the post. Anyway, this discussion is no longer cost/effective in saving lives, so I'm out. Take care.
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No worries. As I said, if you need epidemiological/study design on a vitamin D RCT, I am happy to provide it for free. These things are important!
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Replying to @GidMK @Rootclaim
That's highly appreciated. May take you up on it. Thank you!
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