4. Where is the challenge in giving to 50 hospitalized patients a safe oral treatment every few days? Why would anyone drop out? 5. Search "multivariate logistic regression" in the paper. 6...
It's pretty complex, but basically once you're into the single digits it's hard to draw much meaning from logistic models i.e.https://bmcmedresmethodol.biomedcentral.com/articles/10.1186/s12874-016-0267-3#Sec12 …
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They discuss overestimation of covariate-outcome relation. In our case where the covariates are the risk factors, it means the effect of VitD is actually larger. In any case, even if you assume only people with hypertension go to ICU, the result is significant (see our analysis).
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I mean, that's not true and it mostly misses the point so...I disagree. It really comes back to the fact that a tiny pilot study doesn't form a strong basis for decision-making
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