It's amazing how, dozens/hundreds of studies and months into the research of COVID-19 and Vitamin D and given the quality of the research it's STILL impossible to know the answer to the only important question (does supplementation do anything?) with any certainty
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Just astonishing that, despite the nonsense headlines and supplement grifter claims, the evidence for Vit D supplementation as a treatment for COVID-19 is so woeful that we have no idea if it does anything at all
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Replying to @GidMK
Good trial: > “Of 50 patients treated with calcifediol, one required admission to the ICU (2%), while of 26 untreated patients, 13 required admission (50%)”. Even if not proven; a year's supply of D at 5000IU/day only costs $13. https://www.amazon.com/NatureWise-Vitamin-Function-Cold-Pressed-Gluten-Free/dp/B00GB85JR4/ref=sr_1_6?dchild=1&keywords=vitamin+d+5000+iu&qid=1601176958&sr=8-6 …https://covid.us.org/2020/09/03/new-study-vitamin-d-reduces-risk-of-icu-admission-97/ …
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Replying to @Hoytster
Nope, that was a pretty terrible trial! Poor blinding, allocation concealment totally absent, any number of other issues. Also very small
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Replying to @Hoytster
That's not true. Allocation concealment means concealing the order of randomisation from the people allocating participants. In this study, as they say in the methods, the physicians conducting the randomisation had access to the randomisation schedule
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Replying to @Hoytster
That's literally it. Nonmasked specialists could access the list, meaning that allocation was not concealed
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Evaluating results is not the point, it is who gets to allocate patients into groups. If you're interested in allocation concealment and why this is an issue, the Cochrane handbook is a good read
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