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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK 8 Sep 2020

      Health Nerd Retweeted Health Nerd

      I thought I'd look at this paper in a little bit more detail because, well, there are some pretty big issues Let's do some peer-review on twitter!https://twitter.com/GidMK/status/1303539430024568832 …

      Health Nerd added,

      Health NerdVerified account @GidMK
      So, >80% of you people would either be pretty skeptical of a paper like this or wouldn't trust it at all Yes, it is indeed a real paper https://twitter.com/GidMK/status/1302857005531459584 … pic.twitter.com/iWFg5cEIdS
      Show this thread
      5 replies 18 retweets 65 likes
      Show this thread
    2. Health Nerd‏Verified account @GidMK 8 Sep 2020

      The study is here: https://www.sciencedirect.com/science/article/pii/S0960076020302764?via%3Dihub#tbl0015 … Already up to an Altmetric of 2,543, the highest ever for the journal it's inpic.twitter.com/9GGjp7q8Gg

      2 replies 1 retweet 8 likes
      Show this thread
    3. Health Nerd‏Verified account @GidMK 8 Sep 2020

      The authors randomly assigned people to either get treatment as usual or calcifediol, which is a product of vitamin D metabolism, and then checked how many went into ICU or died in the two groups

      1 reply 1 retweet 5 likes
      Show this thread
    4. Health Nerd‏Verified account @GidMK 8 Sep 2020

      The findings were, to put it bluntly, astonishing Of the intervention group, only 1/50 patients went to ICU Of the control, 13/50 went to ICU, 2 of whom died So calcifediol reduced ICU admission by ~90%!pic.twitter.com/h9hSt4cL11

      3 replies 1 retweet 7 likes
      Show this thread
    5. Health Nerd‏Verified account @GidMK 8 Sep 2020

      However, it doesn't take long to see some major caveats to this research Firstly, it was not blinded. Treating clinicians - who were the ones in charge of sending a patient to ICU - knew who was getting the treatment and who wasn't

      2 replies 0 retweets 14 likes
      Show this thread
    6. Vivien Shotwell ♪‏ @vivienshotwell 9 Sep 2020
      Replying to @GidMK

      Given that 20%-40% of hospitalized Covid-19 patients in the U.S. are sent to ICU, could bias from treating clinicians really account for only 1 in 50 of the Spanish group being sent to the ICU? If bias kept patients from ICU, wouldn't more have died?https://www.upi.com/Health_News/2020/09/09/Study-1-in-5-young-adults-hospitalized-with-COVID-19-require-ICU/2281599656827/ …

      1 reply 0 retweets 0 likes
      Health Nerd‏Verified account @GidMK 9 Sep 2020
      Replying to @vivienshotwell

      Since it wasn't blinded, bias could easily be present in a number of ways. That's the problem with potential sources of bias - hard to say for sure!

      4:15 PM - 9 Sep 2020
      • 1 Like
      • Vivien Shotwell ♪
      1 reply 0 retweets 1 like
        1. New conversation
        2. Health Nerd‏Verified account @GidMK 9 Sep 2020
          Replying to @GidMK @vivienshotwell

          One example - there was an electronically generated randomization schedule (good) that was accessible to the people responsible for group assignment (less good). Could've just been that they randomized sicker people to not get the treatment

          1 reply 0 retweets 0 likes
        3. Vivien Shotwell ♪‏ @vivienshotwell 11 Sep 2020
          Replying to @GidMK

          That makes sense, but even if there weren't a control group, wouldn't those numbers (1 in 50) be remarkable in themselves? I know they could've chosen 50 healthy-yet-hospitalized ~70-year-olds, but there's no money in vitamin D and it's safe. Why not try it until proven wrong?

          0 replies 0 retweets 0 likes
        4. End of conversation

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