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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK 8 Sep 2020

      The study is here: https://www.sciencedirect.com/science/article/pii/S0960076020302764?via%3Dihub#tbl0015 … Already up to an Altmetric of 2,543, the highest ever for the journal it's inpic.twitter.com/9GGjp7q8Gg

      2 replies 1 retweet 8 likes
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    2. Health Nerd‏Verified account @GidMK 8 Sep 2020

      The authors randomly assigned people to either get treatment as usual or calcifediol, which is a product of vitamin D metabolism, and then checked how many went into ICU or died in the two groups

      1 reply 1 retweet 5 likes
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    3. Health Nerd‏Verified account @GidMK 8 Sep 2020

      The findings were, to put it bluntly, astonishing Of the intervention group, only 1/50 patients went to ICU Of the control, 13/50 went to ICU, 2 of whom died So calcifediol reduced ICU admission by ~90%!pic.twitter.com/h9hSt4cL11

      3 replies 1 retweet 7 likes
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    4. Health Nerd‏Verified account @GidMK 8 Sep 2020

      However, it doesn't take long to see some major caveats to this research Firstly, it was not blinded. Treating clinicians - who were the ones in charge of sending a patient to ICU - knew who was getting the treatment and who wasn't

      2 replies 0 retweets 14 likes
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    5. Health Nerd‏Verified account @GidMK 8 Sep 2020

      There was also no placebo control, again introducing a potential source of bias into the arrangement On top of this, the sample was very small (n=76)

      1 reply 0 retweets 10 likes
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    6. Health Nerd‏Verified account @GidMK 8 Sep 2020

      Now, all of this is fine, because you see this was a PILOT trial The actual big research project is ongoing, and will involve >10x as many people!pic.twitter.com/cHPCo0z4P1

      1 reply 0 retweets 7 likes
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    7. Health Nerd‏Verified account @GidMK 8 Sep 2020

      But there are some issues in the study that don't have anything to do with the pilot nature For example, this flow diagrampic.twitter.com/J3c0GQSSQC

      1 reply 0 retweets 3 likes
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    8. Health Nerd‏Verified account @GidMK 8 Sep 2020

      This diagram implies that of the patients who were screened for the study (PCR+, pneumonia on radiograph, clinical infection) 100% were enrolled 100% of those patients were randomized 100% took the treatment as assigned 100% were followed up until the end of the study

      2 replies 0 retweets 7 likes
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    9. Health Nerd‏Verified account @GidMK 8 Sep 2020

      Now, I don't know if that is entirely unheard of, but thus far I have never seen such perfect numbers. Even other in-hospital trials of drugs for COVID-19 have a handful of patients drop out (or at least 1 patient screened who was not eligible!)

      3 replies 0 retweets 11 likes
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    10. This Tweet is unavailable.
      Health Nerd‏Verified account @GidMK 8 Sep 2020

      Perhaps, but 100% screened were eligible, consented, and stayed until the end of the trial with no loss to follow-up. As I said, I've never seen anything even remotely like that before

      10:19 PM - 8 Sep 2020
      0 replies 0 retweets 0 likes

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