I thought I'd look at this paper in a little bit more detail because, well, there are some pretty big issues Let's do some peer-review on twitter!https://twitter.com/GidMK/status/1303539430024568832 …
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Also, the control group had higher levels of hypertension and diabetes compared to the intervention group. This is acknowledged by the authors as a limitation, and is definitely not ideal when making conclusions based on the resultspic.twitter.com/XM3KjauodY
It is entirely possible - perhaps even likely - that one of these potential sources of bias influenced the eventual results. A study like this would be rated as at a "very high" risk of bias in most formal assessments
I think most scientists would just read this as a tiny pilot study, and await better data That's certainly my opinion - there are too many potential sources of bias here to make any solid conclusions
Unfortunately, it is the age of COVID-19, so this study has instead gone viral on social media and is being used to recommend that people take vitamin D supplements Such is the way of 2020
I should also mention that this is not in any way an indictment of the study's authors. This was clearly meant to be a pilot study, and should be read as such It is just a shame that people have instead sensationalized the research
Perhaps, but 100% screened were eligible, consented, and stayed until the end of the trial with no loss to follow-up. As I said, I've never seen anything even remotely like that before
Interesting thread, can you say more about the particular forms bias you're worried about?
To be fair, the endpoints were discharge, ICU admission, or death so it makes sense that every single patient would fall into *one* of those. To me, besides blinding, the biggest thing I’d like to have seen was BMI/obesity and 25(OH)D level monitoring...
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