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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK 19 Aug 2020

      19/n That's a big issue because you can't really combine the effect of coffee with diphenhydramine and expect it to make sense, but that's what the authors did

      2 replies 2 retweets 41 likes
      Show this thread
    2. Health Nerd‏Verified account @GidMK 19 Aug 2020

      20/n Ultimately, I think the only real conclusion you can draw here is that we have very little idea whether honey reduces symptoms for URTI/cough, and that the research is quite problematic

      1 reply 9 retweets 68 likes
      Show this thread
    3. Health Nerd‏Verified account @GidMK 19 Aug 2020

      21/n Not something that'll make headlines, perhaps, but sadly that's often how these things go

      1 reply 0 retweets 38 likes
      Show this thread
    4. Health Nerd‏Verified account @GidMK 19 Aug 2020

      22/n N.B. this study has already hit ~800 on Altmetric, been covered internationally, and made huge newspic.twitter.com/bj72yqShfA

      3 replies 0 retweets 38 likes
      Show this thread
    5. Health Nerd‏Verified account @GidMK 19 Aug 2020

      23/n Something else I didn't mention. Every study that I've looked at so far used a per-protocol analysis, which is a huge and worrying issue All of these should be at a high risk of attrition bias, yet none were rated as such. Most of them were green (low risk)pic.twitter.com/Y6sXlnkJHe

      2 replies 1 retweet 37 likes
      Show this thread
    6. Health Nerd‏Verified account @GidMK 19 Aug 2020

      24/n I've gotta say, for anyone teaching students about how finicky bias can be in systematic reviews, this is a beautiful example of getting it wrong

      4 replies 10 retweets 81 likes
      Show this thread
    7. Health Nerd‏Verified account @GidMK 19 Aug 2020

      25/n Somehow there are more issues here. This study was included in the risk of bias, but even though it assessed honey vs placebo/salbutamonl (and found no effect) it is not in any of the meta-analyses Very weirdpic.twitter.com/8AaMA85ERm

      1 reply 1 retweet 34 likes
      Show this thread
    8. Health Nerd‏Verified account @GidMK 19 Aug 2020

      26/n This is even weirder when you consider that the authors report excluding a study for not providing data So they exclude one study and report it, but another just...disappears? So strangepic.twitter.com/oyrp57yP1Y

      2 replies 0 retweets 26 likes
      Show this thread
    9. Health Nerd‏Verified account @GidMK 19 Aug 2020

      27/n Another included study using a per-protocol analysis. This was at least rated correctly as at a high risk of biaspic.twitter.com/t2mRMIq539

      1 reply 0 retweets 20 likes
      Show this thread
    10. Health Nerd‏Verified account @GidMK 19 Aug 2020

      28/n Another one. This study was rated at low risk of bias for most domains. Here's how they described their randomization and allocation concealment. What do you think?pic.twitter.com/1NM606xcRg

      1 reply 1 retweet 26 likes
      Show this thread
      Health Nerd‏Verified account @GidMK 19 Aug 2020

      29/n I'll give you a head-start - if they literally don't report ~how~ patients were randomized, by definition this should be unclear or high risk of bias for the domain of random sequence generation

      8:54 PM - 19 Aug 2020
      • 2 Retweets
      • 65 Likes
      • Fede Breanna Cecil, MS, RD Kamil Paprotny 畑🍊 julia yase-mara Edgar A. Lopez P A R R A✨ Luke Murray Carole Paley
      12 replies 2 retweets 65 likes
        1. New conversation
        2. Andrew Kunzmann‏ @1987Andrewk 20 Aug 2020
          Replying to @GidMK

          Excellent summary. The devil really is in the detail. Frustrating to see so many low quality studies with "optimistic" interpretations as it just polarises debates that seem easy and worthwhile to answer. Did any of the studies seem to be correctly graded as at low risk of bias?

          1 reply 0 retweets 1 like
        3. Health Nerd‏Verified account @GidMK 20 Aug 2020
          Replying to @1987Andrewk

          The only I could find before I gave up was Cohen 2012

          0 replies 0 retweets 1 like
        4. End of conversation
        1. New conversation
        2. Tom Andrews 💙‏ @0bj3ctivity 20 Aug 2020
          Replying to @GidMK

          @threadreaderapp unroll

          1 reply 0 retweets 0 likes
        3. Thread Reader App‏ @threadreaderapp 20 Aug 2020
          Replying to @0bj3ctivity

          Hello, the unroll you asked for: @GidMK: A systematic review/meta-analysis of honey vs other cough/cold remedies came out yesterday in BMJ… https://threadreaderapp.com/thread/1296264707922251776.html … Have a good day. 🤖

          0 replies 0 retweets 0 likes
        4. End of conversation
        1. New conversation
        2. Diana Hechavarría 🪐‏ @diana_h 20 Aug 2020
          Replying to @GidMK

          @threadreaderapp unroll

          1 reply 0 retweets 0 likes
        3. Thread Reader App‏ @threadreaderapp 20 Aug 2020
          Replying to @diana_h

          Hello, here is your unroll: @GidMK: A systematic review/meta-analysis of honey vs other cough/cold remedies came out yesterday in BMJ… https://threadreaderapp.com/thread/1296264707922251776.html … Talk to you soon. 🤖

          0 replies 3 retweets 0 likes
        4. End of conversation
        1. New conversation
        2. Jean-Claude Fox‏ @JeanClaudeFox2 20 Aug 2020
          Replying to @GidMK

          I'm not a native speaker, but to me "randomized alternatively" sounds as though all the even numbers went into one group and the odd numbers into the other. Could that be?

          1 reply 0 retweets 0 likes
        3. Health Nerd‏Verified account @GidMK 20 Aug 2020
          Replying to @JeanClaudeFox2

          Possible. The language leaves it open to interpretation

          0 replies 0 retweets 1 like
        4. End of conversation
        1. David Walker‏ @Psych_DW 20 Aug 2020
          Replying to @GidMK

          This is excellent, your thorough deconstruction has provided an excellent example of appraising meta-analyses so much so that I might set this example as an assessment of critical evaluation on an MRes module.

          0 replies 0 retweets 4 likes
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        1. Steve and Deonie Allen‏ @MicroPlastic101 20 Aug 2020
          Replying to @GidMK

          Honey will cure it. A week to 10 days and you are as good as new. *jokes

          0 replies 0 retweets 0 likes
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