The Mayo Clinic convalescent plasma for COVID-19 study is such a depressing waste of time it is frightening After treating THIRTY-FIVE THOUSAND patients, we still have no idea if the treatment workshttps://www.statnews.com/2020/08/13/large-study-suggests-convalescent-plasma-can-help-treat-covid-19-with-caveats …
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Hi! the unroll you asked for:
@GidMK: The Mayo Clinic convalescent plasma for COVID-19 study is such a depressing waste of time it is frightening… https://threadreaderapp.com/thread/1294147265523662849.html … See you soon.
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And they used the word “effect” as the first word of the title

“Effect” implies causality
No randomization = zero ability to decuce causalityThanks. Twitter will use this to make your timeline better. UndoUndo
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It's either an oversight or telling that there's tables for patient characteristics stratified by time period (table 1) and IgG level (table S2) but not for the headline variable of early vs late treatment.
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So you can't even guesstimate the corrections you're talking about from the data presented
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I'm not for one moment suggesting I agree with these authors' conclusions, & I'm not saying it's a good study... but .....pic.twitter.com/SmseuiSK5O
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Yes. But the main finding presented in the news and in interviews appears not to have been adjusted for - they used the bootstrapping for the concentration of antibodies but I cannot see the same methodology used for the 3 vs >=4 days
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