15/n The authors then report using "controls" to adjust the estimates, but these controls are again incredibly misleading For example, country-level obesity ratespic.twitter.com/HGHc9md58T
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26/n Another point that's worth making - the authors say that HCQ is preventive of COVID-19 The methodology is not even vaguely close to what you'd need to know if that's true
27/n You'd want to see case numbers by day, along with every intervention (i.e. social distancing, school closures etc) and the day they were implemented for every country on the list Then, number of HCQ doses given by day AT AN ABSOLUTE MINIMUM
28/n Even if the authors make the suggested changes up until 25/n, they'd just end up with a meaningless correlation without measures like these, which are an enormous amount of work The thing about ecological studies is that the good ones take A LOT of time
29/n Oh, another thing The authors keep maintaining on Twitter that this study was "random" because patients didn't choose what treatment they got, countries did This is absolute nonsense
30/n Firstly, it is misdefining random If ANYONE chooses the treatment, then it's not random BY DEFINITION Random means no one chooses, it's that simple
31/n But also - PATIENTS DID CHOOSE This is where we get back to the ecological fallacy - it is absurd to suggest that individuals within countries didn't choose to take HCQ. Even countries that authorised it had adopters and non-adopters
32/n This protocol was BY NO POSSIBLE DEFINITION "random" Using the term is incorrect, and at best ignorant not just of the scientific terminology but also the colloquial meaning of the word
Are there? Have you actually looked at how many people got HCQ by country?
Not only all that but the authors have gone to great lengths to hide their identities, even paying for a service to hide their details from their website's domain registration. Never a good sign.pic.twitter.com/6HUCMDF2EM
They have also registered several other websites on this ip address including http://c19study.com , which says this...pic.twitter.com/w9X4LpIpMe
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