Based on the description there it looks like a non-randomized trial with a very big potential for confounding by indication or other sources of bias. Need to see the whole trial!
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Replying to @GidMK @MagnetsOh and
If the signal had been this strong wouldn’t the Recovery trial have picked this up by now? Also the fact that it’s in the WSJ is something of a factor in encouraging scepticism.
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1) I have not seen the Recovery trial on convalescent. 2) this trial postulates a strong dose-response relation which Recovery may not have been designed to pick up and 3) this trial is an early administration. It is from Mayo, details will be out, at some point.
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Nobody has seen the Recovery results yet AFAIK. Which means with their protocol the results must be as yet not strong enough to call. Possibly the study differs significantly.
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I don't think it's possible to conclude anything about efficacy from the information presented here. Could be entirely useless, we wouldn't know because the trial is basically not described at all!
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