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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
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@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Jon Deeks FMedSci‏ @deeksj 25 Jun 2020

      #9 also little data beyond 35 days. Don’t know how these tests will hold up for longer duration seroprevalence surveys, or testing for infection which might have occured >5 weeks ago. Antibodies will wain and we don't know when.

      2 replies 5 retweets 8 likes
      Show this thread
    2. Jon Deeks FMedSci‏ @deeksj 25 Jun 2020

      #10 Specificity looked good. Lots of datapic.twitter.com/Dj8NTzi59J

      2 replies 3 retweets 9 likes
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    3. Jon Deeks FMedSci‏ @deeksj 25 Jun 2020

      #11 Other problems included (a) unstated numbers of multiple samples taken from patients in many studies; (b) very rare for tests to be evaluated using blinding; (c) no mentions of exclusions; (d) use of laboratories and venous blood to evaluate finger-prick POC tests.

      1 reply 2 retweets 5 likes
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    4. Jon Deeks FMedSci‏ @deeksj 25 Jun 2020

      #12 Also clear evidence of publication bias as reported previously (from National COVID-19 testing panel)pic.twitter.com/PXvKIFOMig

      1 reply 3 retweets 7 likes
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    5. Jon Deeks FMedSci‏ @deeksj 25 Jun 2020

      #13 And nobody seems to have heard of STARD – not a single patient flow-diagram in the 54 studies. Reporting quality was shockingly poor.

      1 reply 7 retweets 15 likes
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    6. Jon Deeks FMedSci‏ @deeksj 25 Jun 2020

      #14 Bottom lines: (A)TIMING REALLY MATTERS. Don’t use the test before 2 weeks. Studies which have done so many wrongly have decided some tests are useless.

      2 replies 9 retweets 22 likes
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    7. Jon Deeks FMedSci‏ @deeksj 25 Jun 2020

      #15 (B)TEST COULD HELP IDENTIFY COVID-19 IN PATIENTS WITH SYMPTOMS FOR >2 WEEKS. This could be useful given the lack of PCR testing in patients who suffered at home without a test, some of whom may still be sick and need medical care. Is anybody doing this?

      1 reply 3 retweets 17 likes
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    8. Jon Deeks FMedSci‏ @deeksj 25 Jun 2020

      #16 (C)WE DON’T KNOW WHETHER IT KEEPS WORKING > 5 WEEKS hopefully we’ll find some longer follow-up studies soon.

      3 replies 2 retweets 16 likes
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    9. Jacob Gudiol‏Verified account @JacobGudiol 25 Jun 2020
      Replying to @deeksj

      Have you looked at the date of the seroprevalence studies in your meta-analysis @GidMK to see if the IFR varies depending on when the tests were performed in relation to when different outbreaks peaked? I wonder if IFR is higher if the delay between peak & date of test increases

      1 reply 0 retweets 0 likes
    10. Jacob Gudiol‏Verified account @JacobGudiol 25 Jun 2020
      Replying to @JacobGudiol @deeksj @GidMK

      There has been a couple of studies lately pointing to the possibility that antibodies are missing after a couple of weeks in those with mild symptoms For example https://www.nature.com/articles/s41591-020-0965-6#Sec9 …

      1 reply 0 retweets 0 likes
      Health Nerd‏Verified account @GidMK 25 Jun 2020
      Replying to @JacobGudiol @deeksj

      Not really what I'm seeing in the longitudinal studies. Finland, Switzerland, etc all either maintain a similar % positive or go up week by week

      12:47 PM - 25 Jun 2020
      1 reply 0 retweets 0 likes
        1. New conversation
        2. Jonas Lannergård‏ @Jion47 29 Jun 2020
          Replying to @GidMK @JacobGudiol @deeksj

          All IgG have a serum half life around 21 days, so seems unlikely that titers would go below detection within a few weeks specifically in those with mild symptoms.

          1 reply 0 retweets 0 likes
        3. Jacob Gudiol‏Verified account @JacobGudiol 29 Jun 2020
          Replying to @Jion47 @GidMK @deeksj

          Jacob Gudiol Retweeted Karolinska Institutet

          https://twitter.com/karolinskainst/status/1277660017848614912 …

          Jacob Gudiol added,

          Karolinska Institutet @karolinskainst
          New unpublished results from KI and @KarolinskaUnsju shows that many with mild or asymptomatic #COVID19 show #tcell immunity to the new #coronavirus, even if they don’t have antibodies. This means #Immunity is probably higher than antibody tests suggest. https://bit.ly/2ZklrR5  pic.twitter.com/WiThZQs2Ri
          1 reply 0 retweets 0 likes
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