One drug costs $12 a month The other costs $12000 a month
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One trial is run by academics without financial stake in the outcome The other is run by a corporation with billions of dollars at stake, by 'academics' who are likely paid by the company, designed with the goal of winning the FDA seal of approval
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One trial has a 35 page published protocol you can read right now, and I did: https://www.recoverytrial.net/files/recovery-protocol-v6-0-2020-05-14.pdf … The other doesn't, and with NEJM these days, might end up with only a redacted one online ultimately
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One trial improves all cause mortality in critically ill patients The other improves invasive disease free survival (iDFS) in women with early breast cancer s/p surgery who mostly do well, and where many are cured already Wait? what is IDFS?
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Its a newly invented outcome that has an awful correlation with overall survival, and if we were really honest would not exist https://pubmed.ncbi.nlm.nih.gov/18029973/ Oh, right.. as you were saying..
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One trial has very few ways to game it (having read the protocol) The other has many many ways it could be distorted or biased (having not read the protocol, but lived on planet earth long enough to read many cancer drug trials)
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So in short 'medicine by press release' is adopting practice based on the latter type of press release, and not the former Yes, absolutely I will read both papers in full and supplements, but these are not the same
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One you should act on today The other you should definitely wait for the paper, wait for FDA approval, and most of all wait for
@Plenary_Session to discuss Hope that helps!3 replies 5 retweets 70 likesShow this thread -
Agree?
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Vinay Prasad, MD MPH 🎙️ 📷 Retweeted Darren Dahly, PhD
Update: many thoughtful folks have pointed out the authors could have posted a preprint within 24hrs My 2 c. Yes, absolutely, they are right. What good is medical residency if not to prepare u to pull an all nighter and write this up in < 24 hrshttps://twitter.com/statsepi/status/1273130059650469888?s=20 …
Vinay Prasad, MD MPH 🎙️ 📷 added,
Darren Dahly, PhD @statsepi...they were analyzed, so the code/scripts already exist as well. The discussion can be a single paragraph at this point. So what I don't understand is why we can't just get a decent preprint out w/in 24 hours allowing other to at least interrogate the result.Show this thread5 replies 6 retweets 19 likesShow this thread
Are you seriously suggesting that this enormous scientific effort didn't have a draft paper already written days/weeks ago? At the very least, given that it's govt involved, there's a detailed report with an executive summary with all the pertinent information
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