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GidMK's profile
Health Nerd
Health Nerd
Health Nerd
Verified account
@GidMK

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Health NerdVerified account

@GidMK

Epidemiologist. Writer (Guardian, Observer etc). "Well known research trouble-maker". PhDing at @UoW Host of @senscipod Email gidmk.healthnerd@gmail.com he/him

Sydney, New South Wales
theguardian.com/profile/gideon…
Joined November 2015

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    1. Health Nerd‏Verified account @GidMK 8 Jun 2020

      22/n (One thing that gives you an answer more similar to the number they've got is calculating odds based on the %s given in the KM curve rather than the crude figures, but that has its own issues)

      1 reply 0 retweets 12 likes
      Show this thread
    2. Health Nerd‏Verified account @GidMK 8 Jun 2020

      23/n There's also no reasoning given for including multiple different outcomes from the SAME PATIENTS in a meta-analysis This is very concerning

      1 reply 1 retweet 15 likes
      Show this thread
    3. Health Nerd‏Verified account @GidMK 8 Jun 2020

      24/n For example, they've got some studies where they included numbers on the likelihood of a "clinical cure" AND "death" from the same patients These are obviously related, so aggregating both in the same model is...problematic

      1 reply 3 retweets 12 likes
      Show this thread
    4. Health Nerd‏Verified account @GidMK 8 Jun 2020

      25/n It's also worth noting that several of these retrospective clinical audits were from the same places at overlapping times, and so probably included some of the same patients anyway

      1 reply 0 retweets 10 likes
      Show this thread
    5. Health Nerd‏Verified account @GidMK 8 Jun 2020

      26/n There are, somehow, even more issues to examine here For one thing, the review protocol was poorly described and hard to followpic.twitter.com/AVrJ50Kx6s

      1 reply 0 retweets 6 likes
      Show this thread
    6. Health Nerd‏Verified account @GidMK 8 Jun 2020

      27/n Remember; this is the pre-proof version of the study In other words, the final, slightly unedited, publishable version In that context, this methodology is FAR too opaque

      1 reply 1 retweet 11 likes
      Show this thread
    7. Health Nerd‏Verified account @GidMK 8 Jun 2020

      28/n The results show you what I'm talking about There is NO WAY that searching with those search terms gets you only 23 studies Even just plugging in the search terms to PubMed gives you >100 studiespic.twitter.com/73Qn7v1x9u

      1 reply 0 retweets 13 likes
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    8. Health Nerd‏Verified account @GidMK 8 Jun 2020

      29/n It took me less than 5 minutes to find a study that matches the inclusion criteria but was not included That's...worrying

      1 reply 2 retweets 28 likes
      Show this thread
    9. Health Nerd‏Verified account @GidMK 8 Jun 2020

      30/n On top of that, in some cases the authors have included older versions of the included studies That's less than ideal (newer versions CORRECT mistakes!)

      1 reply 0 retweets 15 likes
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    10. Health Nerd‏Verified account @GidMK 8 Jun 2020

      31/n There is so much more I could look at here, but honestly you have to stop somewhere This study is riddled with flaws and almost certainly does not present an accurate estimate of the effect of HCQ or CQ

      4 replies 3 retweets 21 likes
      Show this thread
      Health Nerd‏Verified account @GidMK 8 Jun 2020

      32/n If you want a decent summation of the evidence for/against HCQ, a good source is CEBM: "Current data do not support the use of hydroxychloroquine for prophylaxis or treatment of COVID-19"https://www.cebm.net/covid-19/hydroxychloroquine-for-covid-19-what-do-the-clinical-trials-tell-us/ …

      8:56 PM - 8 Jun 2020
      • 5 Retweets
      • 22 Likes
      • Apex🌲🏴‍☠️🚀 GrosNiᐰis 💉💉 FrenchJeanGuy 🌿⌬ArSchi⌬🌿 2/2💉 Xypocat R. Ramirez Morales Amaras Tosh`iki Indy🔻#BLM
      2 replies 5 retweets 22 likes
        1. New conversation
        2. Health Nerd‏Verified account @GidMK 8 Jun 2020

          33/n I forgot to mention, the paper was received, revised, and accepted within a month While not unheard of, that's very quick for academic publishing!pic.twitter.com/UgR3WO2BPB

          2 replies 2 retweets 14 likes
          Show this thread
        3. Health Nerd‏Verified account @GidMK 8 Jun 2020

          34/n In summation, the paper: - inadequately rates risk of bias - inappropriately combines estimates... - ...that may have been miscalculated It is hard to know what to make of this, except to say that the paper itself is not very useful in any way

          2 replies 6 retweets 29 likes
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        4. End of conversation
        1. New conversation
        2. Isaac Núñez‏ @IsaacNunezs 8 Jun 2020
          Replying to @GidMK

          Thanks for the thread! @threadreaderapp unroll

          1 reply 0 retweets 1 like
        3. Thread Reader App‏ @threadreaderapp 8 Jun 2020
          Replying to @IsaacNunezs

          Guten tag, the unroll you asked for: @GidMK: Ok, I'm inspired by @MicrobiomDigest to do a bit of actual critical appraisal on this new paper by Raoult et al… https://threadreaderapp.com/thread/1270198888822009856.html … See you soon. 🤖

          0 replies 0 retweets 1 like
        4. End of conversation

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