Lots of people have hypothesized about potential pathways of action, but I think we'd need far more evidence to make any claims either way about them
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Surely the TLDR quote is “but broadly speaking they fall into two categories — the really bad and the truly, unforgivably awful.”
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On the bright side, I find the proliferation of pre-prints these days very refreshing, because it cirumvents the epidemic of corruption in peer review, where it has (often!) become a game where the author's rivals to anonymously obstruct research.
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