I don't understand how they can ethically justify not including a control arm. There's no knowledge about benefit here, so any treatment is pretty speculative - even if there's a benefit in one of the arms we still won't really have much info on whether it works
But according to STAT, their 2400-person trial is comparing 5-day use of remdesivir with 10-day and no control of any kind. Doesn't have to be placebo - they could use an active control!
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I'd say for this a control arm would be usual care at the very least, probably including some other speculative medication. Otherwise we simply won't know if remsividir is better than anything else, we'll just know whether 5-days beats 10-days
End of conversation
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