Wow
Reasonably large RCT of high-dose chloroquine vs low-dose chloroquine (all patients received azithro)
At 6 days, high-dose CQ group had 17% mortality compared to 10% in the low-dose group
No benefit to high-dose CQ on lung parameters, trial stopped earlyhttps://twitter.com/BrianDunning/status/1249825311354650629 …
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Replying to @GidMK @DrJenGunter
So they only stopped the high dose arm per preprint? Also, only compared with hx controls for no tx , no placebo arm. I agree that we shouldn’t jump on HCQ bandwagon, but would like more definitive data. But appears that all this showed was a trend towards >tox in high dose?
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Replying to @shopwithoutkids @DrJenGunter
Pretty much. According to preprint, CQ/HCQ was mandated as a treatment at a federal level in Brazil, so both arms had to receive it. Higher dose appeared to be dying more so trial halted early
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Interesting. Maybe the language was confused? It implied that the patients were required to have the drug
4:38 AM - 14 Apr 2020
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