Wow
Reasonably large RCT of high-dose chloroquine vs low-dose chloroquine (all patients received azithro)
At 6 days, high-dose CQ group had 17% mortality compared to 10% in the low-dose group
No benefit to high-dose CQ on lung parameters, trial stopped earlyhttps://twitter.com/BrianDunning/status/1249825311354650629 …
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See
@UCSF Prof.@annieluet on dosage, i.e., totally unclear if there's useful effect, and if there is, the right dosage, high enough for effect, without causing problems. Of course, that's HCQ, not CQ.https://twitter.com/JohnMashey/status/1246126115841658882 …
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From
@annieluet's earlier talk, it seems that IF HCQ is useful, there's a narrow combination of {timing within COVID, dosage, patient comorbidities, patient variation} that clinicians must figure out when patient presents: https://twitter.com/JohnMashey/status/1245604257824301056 … a3-a14, especially a5 with horse.
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